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dc.contributor.authorKennedy, Kelsey M.
dc.contributor.authorChin, Lixin
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorMcLaughlin, Robert A.
dc.contributor.authorLatham, Bruce
dc.contributor.authorSampson, David D.
dc.contributor.authorSaunders, Christobel M.
dc.contributor.authorKennedy, Brendan F.
dc.date.accessioned2020-02-28T13:30:03Z
dc.date.available2020-02-28T13:30:03Z
dc.date.issued2016-11-09
dc.identifier266562858
dc.identifier8fe38222-4b6b-4fb2-9014-22fc94d27a19
dc.identifier84994854349
dc.identifier27829404
dc.identifier.citationKennedy , K M , Chin , L , Wijesinghe , P , McLaughlin , R A , Latham , B , Sampson , D D , Saunders , C M & Kennedy , B F 2016 , ' Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes ' , BMC Cancer , vol. 16 , 874 . https://doi.org/10.1186/s12885-016-2911-zen
dc.identifier.issn1471-2407
dc.identifier.otherORCID: /0000-0002-8378-7261/work/69835208
dc.identifier.urihttps://hdl.handle.net/10023/19552
dc.descriptionThis project is supported with funding from the Australian Research Council; and Cancer Council WA, which allowed us to develop the technology; Department of Health of Western Australia, National Breast Cancer Foundation (Australia); and the National Health and Medical Research Council, Australia, which allowed us to design and implement the clinical protocol, and to perform the clinical measurements.en
dc.description.abstractBackground : Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer. In this study, we scan axillary lymph nodes, freshly excised from breast cancer patients, with optical coherence micro-elastography (OCME), a method of imaging micro-scale mechanical strain, to assess its potential for the intraoperative assessment of lymph node involvement. Methods : Twenty-six fresh, unstained lymph nodes were imaged from 15 patients undergoing mastectomy or breast-conserving surgery with axillary clearance. Lymph node specimens were bisected to allow imaging of the internal face of each node. Co-located OCME and optical coherence tomography (OCT) scans were taken of each sample, and the results compared to standard post-operative hematoxylin-and-eosin-stained histology. Results : The optical backscattering signal provided by OCT alone may not provide reliable differentiation by inspection between benign and malignant lymphoid tissue. Alternatively, OCME highlights local changes in tissue strain that correspond to malignancy and are distinct from strain patterns in benign lymphoid tissue. The mechanical contrast provided by OCME complements the optical contrast provided by OCT and aids in the differentiation of malignant tumor from uninvolved lymphoid tissue. Conclusion : The combination of OCME and OCT images represents a promising method for the identification of malignant lymphoid tissue. This method shows potential to provide intraoperative assessment of lymph node involvement, thus, preventing unnecessary removal of uninvolved tissues and improving patient outcomes.
dc.format.extent9
dc.format.extent2495916
dc.language.isoeng
dc.relation.ispartofBMC Canceren
dc.subjectBreast canceren
dc.subjectLymph nodeen
dc.subjectOptical coherence tomographyen
dc.subjectElastographyen
dc.subjectMechanical propertiesen
dc.subjectIntraoperativeen
dc.subjectQH426 Geneticsen
dc.subjectR Medicine (General)en
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectCancer Researchen
dc.subjectGeneticsen
dc.subjectOncologyen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH426en
dc.subject.lccR1en
dc.subject.lccRC0254en
dc.titleInvestigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doi10.1186/s12885-016-2911-z
dc.description.statusPeer revieweden


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