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Early-life adversity programs long-term cytokine and microglia expression within the HPA axis in female Japanese quail
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dc.contributor.author | Walker, David J. | |
dc.contributor.author | Zimmer, Cédric | |
dc.contributor.author | Larriva Hormigos, Maria | |
dc.contributor.author | Healy, Susan D. | |
dc.contributor.author | Spencer, Karen A. | |
dc.date.accessioned | 2020-02-27T00:32:11Z | |
dc.date.available | 2020-02-27T00:32:11Z | |
dc.date.issued | 2019-02-27 | |
dc.identifier | 258549800 | |
dc.identifier | d64077ce-be24-4a40-8248-6bae4100a7ee | |
dc.identifier | 85063640811 | |
dc.identifier | 000462866500001 | |
dc.identifier.citation | Walker , D J , Zimmer , C , Larriva Hormigos , M , Healy , S D & Spencer , K A 2019 , ' Early-life adversity programs long-term cytokine and microglia expression within the HPA axis in female Japanese quail ' , Journal of Experimental Biology , vol. 222 , jeb187039 . https://doi.org/10.1242/jeb.187039 | en |
dc.identifier.issn | 0022-0949 | |
dc.identifier.other | ORCID: /0000-0002-8059-4480/work/60631272 | |
dc.identifier.other | ORCID: /0000-0002-2851-9379/work/78204977 | |
dc.identifier.uri | https://hdl.handle.net/10023/19542 | |
dc.description | This work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC grant no. BB/L002264/1 to K.A.S., C.Z. and S.D.H.), a David Phillips Research Fellowship (K.A.S.) and an EASTBIO BBSRC Doctoral Training Programme studentship (grant no. BB/J01446X/1 to D.J.W., supervisors K.A.S., S.D.H.). Data are available from Mendeley (Walker, 2019): http://dx.doi.org/10.17632/ 6r7d2pg2zk.1 | en |
dc.description.abstract | Stress exposure during prenatal and postnatal development can have persistent and often dysfunctional effects on several physiological systems, including immune function, affecting the ability to combat infection. The neuroimmune response is inextricably linked to the action of the hypothalamic–pituitary–adrenal (HPA) axis. Cytokines released from neuroimmune cells, including microglia, activate the HPA axis, while glucocorticoids in turn regulate cytokine release from microglia. Because of the close links between these two physiological systems, coupled with potential for persistent changes to HPA axis activity following developmental stress, components of the neuroimmune system could be targets for developmental programming. However, little is known of any programming effects of developmental stress on neuroimmune function. We investigated whether developmental stress exposure via elevated prenatal corticosterone (CORT) or postnatal unpredictable food availability had long-term effects on pro- (IL-1β) and anti-inflammatory (IL-10) cytokine and microglia-dependent gene (CSF1R) expression within HPA axis tissues in a precocial bird, the Japanese quail (Coturnix japonica). Following postnatal stress, we observed increased IL-1β expression in the pituitary gland, reduced IL-10 expression in the amygdala and hypothalamus, and reduced CSF1R expression within the hypothalamus and pituitary gland. Postnatal stress disrupted the ratio of IL-1β:IL-10 expression within the hippocampus and hypothalamus. Prenatal stress only increased IL-1β expression in the pituitary gland. We found no evidence for interactive or cumulative effects across life stages on basal cytokine and glia expression in adulthood. We show that postnatal stress may have a larger impact than elevated prenatal CORT on basal immunity in HPA-axis-specific brain regions, with changes in cytokine homeostasis and microglia abundance. These results provide evidence for postnatal programming of a pro-inflammatory neuroimmune phenotype at the expense of reduced microglia, which could have implications for central nervous system health and subsequent neuroimmune responses. | |
dc.format.extent | 11 | |
dc.format.extent | 753342 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Experimental Biology | en |
dc.subject | Cytokines | en |
dc.subject | Developmental programming | en |
dc.subject | Glucocorticoids | en |
dc.subject | Neuroinflammation | en |
dc.subject | Anti-inflammatory | en |
dc.subject | Neuroimmune | en |
dc.subject | QH301 Biology | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | DAS | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC0321 | en |
dc.title | Early-life adversity programs long-term cytokine and microglia expression within the HPA axis in female Japanese quail | en |
dc.type | Journal article | en |
dc.contributor.sponsor | BBSRC | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Centre for Biological Diversity | en |
dc.contributor.institution | University of St Andrews. Centre for Social Learning & Cognitive Evolution | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Coastal Resources Management Group | en |
dc.identifier.doi | 10.1242/jeb.187039 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-02-27 | |
dc.identifier.grantnumber | BB/L002264/1 | en |
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