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dc.contributor.authorSchertzinger, Meredith Marie
dc.contributor.authorWesson-Sides, Kate
dc.contributor.authorParkitny, Luke
dc.contributor.authorYounger, Jarred
dc.identifier.citationSchertzinger , M M , Wesson-Sides , K , Parkitny , L & Younger , J 2018 , ' Daily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severity ' , The Journal of Pain , vol. 19 , no. 4 , pp. 410-417 .
dc.identifier.otherPURE: 266341461
dc.identifier.otherPURE UUID: 68dc800a-fc5e-46f7-a34e-38ab6c6e9102
dc.identifier.otherORCID: /0000-0002-0429-8858/work/69029623
dc.identifier.otherScopus: 85040935057
dc.description.abstractThe purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Corti- sol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity. In the entire sample, day to day changes in progesterone (P = .002) as well as tes- tosterone (P = .015) were significantly and inversely correlated with pain severity. There was no relationship between estradiol and pain (P = .551) or cortisol and pain (P = .633). These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to increase as well as decrease fibromyalgia pain severity.
dc.relation.ispartofThe Journal of Painen
dc.rightsCopyright © 2017 The Author(s). Published by Elsevier Inc. on behalf of the American Pain Society. This is an open access article under the CC BY-NC-ND license (
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleDaily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severityen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.description.statusPeer revieweden

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