St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

The X files : ''The mystery of X chromosome instability in Alzheimer's disease''

Thumbnail
View/Open
Bajic_2020_FG_XFiles_CC.pdf (656.8Kb)
Date
28/01/2020
Author
Bajic, Vladan P.
Essak, Mugbubah
Zivkovic, Lada
Stewart, Alan
Zafirovic, Sonja
Bajic, Vladimir
Gojobori, Takashi
Isenovic, Esma
Spremo-Potparevic, Biljana
Keywords
X chromosome
Alzheimer's disease
Sex chromosome dosage
Protocadherin 11
Centromere instabiility
QH426 Genetics
Metadata
Show full item record
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics.
Citation
Bajic , V P , Essak , M , Zivkovic , L , Stewart , A , Zafirovic , S , Bajic , V , Gojobori , T , Isenovic , E & Spremo-Potparevic , B 2020 , ' The X files : ''The mystery of X chromosome instability in Alzheimer's disease'' ' , Frontiers in Genetics , vol. 10 , 1368 . https://doi.org/10.3389/fgene.2019.01368
Publication
Frontiers in Genetics
Status
Peer reviewed
DOI
https://doi.org/10.3389/fgene.2019.01368
ISSN
1664-8021
Type
Journal item
Rights
Copyright © 2020 Bajic, Essack, Zivkovic, Stewart, Zafirovic, Bajic, Gojobori, Isenovic and Spremo-Potparevic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Description
This work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. This work has been supported by grants No. 173033 (E.R.I.) and No. 173034 (V.P.B) from the Ministry of Education, Science and Technological Development, Republic of Serbia and by the KAUST grant OSR#4129 (to E.R.I. and V.B.B.), which also supported S.Z. and V.P.B.; V.B.B. has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while V.B.B. and M.E. have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01. T.G. has been supported by the King Abdullah University of Science and Technology (KAUST) Base Research Fund (BAS/1/1059-01-411 01).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/19362

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter