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dc.contributor.authorGasperini, Danila
dc.contributor.authorGreenhalgh, Mark
dc.contributor.authorImad, Rehan
dc.contributor.authorSiddiqui, Shehzaib
dc.contributor.authorMalik, Anum
dc.contributor.authorArshad, Fizza
dc.contributor.authorChoudhary, Muhammad Iqbal
dc.contributor.authorAl-Majid, Abdullah
dc.contributor.authorCordes, David
dc.contributor.authorSlawin, Alexandra
dc.contributor.authorNolan, Steven
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2019-12-21T00:36:25Z
dc.date.available2019-12-21T00:36:25Z
dc.date.issued2018-12-21
dc.identifier.citationGasperini , D , Greenhalgh , M , Imad , R , Siddiqui , S , Malik , A , Arshad , F , Choudhary , M I , Al-Majid , A , Cordes , D , Slawin , A , Nolan , S & Smith , A D 2018 , ' Chiral Au I - and Au III -isothiourea complexes : synthesis, characterization and application ' , Chemistry - A European Journal , vol. Early View . https://doi.org/10.1002/chem.201804653en
dc.identifier.issn0947-6539
dc.identifier.otherPURE: 256369559
dc.identifier.otherPURE UUID: b69c546f-1f87-4734-bde7-46d677c5d802
dc.identifier.otherScopus: 85059011049
dc.identifier.otherORCID: /0000-0002-2104-7313/work/52572453
dc.identifier.otherORCID: /0000-0002-5366-9168/work/52572467
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861419
dc.identifier.otherWOS: 000456318800025
dc.identifier.urihttp://hdl.handle.net/10023/19187
dc.descriptionADS thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Facility at Swansea University. SPN thanks King Abdullah University of Science and Technology (Award No. SR-2015-CCF-1974-03) and King Saud University for support.en
dc.description.abstractDuring an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold‐isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air‐ and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)‐isothiourea carbonyl complexes. The novel gold(I)‐ and gold(III)‐isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically‐relevant enzymes.
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.rightsCopyright © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/chem.201804653en
dc.subjectGolden
dc.subjectCoordination chemistryen
dc.subjectN ligandsen
dc.subjectHomogeneous catalysisen
dc.subjectBioinorganic chemistryen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleChiral AuI- and AuIII-isothiourea complexes : synthesis, characterization and applicationen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1002/chem.201804653
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-12-21


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