Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorSteinig, Eike J
dc.contributor.authorDuchene, Sebastian
dc.contributor.authorRobinson, D Ashley
dc.contributor.authorMonecke, Stefan
dc.contributor.authorYokoyama, Maho
dc.contributor.authorLaabei, Maisem
dc.contributor.authorSlickers, Peter
dc.contributor.authorAndersson, Patiyan
dc.contributor.authorWilliamson, Deborah
dc.contributor.authorKearns, Angela
dc.contributor.authorGoering, Richard V
dc.contributor.authorDickson, Elizabeth
dc.contributor.authorEhricht, Ralf
dc.contributor.authorIp, Margaret
dc.contributor.authorO'Sullivan, Matthew V N
dc.contributor.authorCoombs, Geoffrey W
dc.contributor.authorPetersen, Andreas
dc.contributor.authorBrennan, Grainne
dc.contributor.authorShore, Anna C
dc.contributor.authorColeman, David C
dc.contributor.authorPantosti, Annalisa
dc.contributor.authorde Lencastre, Herminia
dc.contributor.authorWesth, Henrik
dc.contributor.authorKobayashi, Nobumichi
dc.contributor.authorHeffernan, Helen
dc.contributor.authorStrommenger, Birgit
dc.contributor.authorLayer, Franziska
dc.contributor.authorWeber, Stefan
dc.contributor.authorAamot, Hege Vangstein
dc.contributor.authorSkakni, Leila
dc.contributor.authorPeacock, Sharon J
dc.contributor.authorSarovich, Derek
dc.contributor.authorHarris, Simon
dc.contributor.authorParkhill, Julian
dc.contributor.authorMassey, Ruth C
dc.contributor.authorHolden, Mathew T G
dc.contributor.authorBentley, Stephen D
dc.contributor.authorTong, Steven Y C
dc.date.accessioned2019-12-16T17:30:03Z
dc.date.available2019-12-16T17:30:03Z
dc.date.issued2019-11-26
dc.identifier.citationSteinig , E J , Duchene , S , Robinson , D A , Monecke , S , Yokoyama , M , Laabei , M , Slickers , P , Andersson , P , Williamson , D , Kearns , A , Goering , R V , Dickson , E , Ehricht , R , Ip , M , O'Sullivan , M V N , Coombs , G W , Petersen , A , Brennan , G , Shore , A C , Coleman , D C , Pantosti , A , de Lencastre , H , Westh , H , Kobayashi , N , Heffernan , H , Strommenger , B , Layer , F , Weber , S , Aamot , H V , Skakni , L , Peacock , S J , Sarovich , D , Harris , S , Parkhill , J , Massey , R C , Holden , M T G , Bentley , S D & Tong , S Y C 2019 , ' Evolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus lineage from the Indian subcontinent ' , mBio , vol. 10 , no. 6 , e01105 , pp. 1-20 . https://doi.org/10.1128/mBio.01105-19en
dc.identifier.issn2150-7511
dc.identifier.otherPURE: 264328012
dc.identifier.otherPURE UUID: 17a29b5d-188f-4ae9-959f-42f3852890fc
dc.identifier.otherPubMed: 31772058
dc.identifier.otherPubMedCentral: PMC6879714
dc.identifier.otherScopus: 85075641618
dc.identifier.otherORCID: /0000-0002-4958-2166/work/66398413
dc.identifier.otherWOS: 000500484800047
dc.identifier.urihttps://hdl.handle.net/10023/19141
dc.descriptionFunding: Australian National Health and Medical Research Council (number 1145033 to Steven Y. C. Tong and number 1065908 to Matthew V. N.O’Sullivan); a National Institutes of Health grant (GM080602 to D. Ashley Robinson); Irish Health Research Board (HRA-POR-2015-1051 to David C. Coleman and Anna C. Shore).en
dc.description.abstractThe evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated Staphylococcus aureus lineage from the Indian subcontinent, the Bengal Bay clone (ST772). We generated whole-genome sequence data of 340 isolates from 14 countries, including the first isolates from Bangladesh and India, to reconstruct the evolutionary history and genomic epidemiology of the lineage. Our data show that the clone emerged on the Indian subcontinent in the early 1960s and disseminated rapidly in the 1990s. Short-term outbreaks in community and health care settings occurred following intercontinental transmission, typically associated with travel and family contacts on the subcontinent, but ongoing endemic transmission was uncommon. Acquisition of a multidrug resistance integrated plasmid was instrumental in the emergence of a single dominant and globally disseminated clade in the early 1990s. Phenotypic data on biofilm, growth, and toxicity point to antimicrobial resistance as the driving force in the evolution of ST772. The Bengal Bay clone therefore combines the multidrug resistance of traditional health care-associated clones with the epidemiological transmission of community-associated methicillin-resistant S. aureus (MRSA). Our study demonstrates the importance of whole-genome sequencing for tracking the evolution of emerging and resistant pathogens. It provides a critical framework for ongoing surveillance of the clone on the Indian subcontinent and elsewhere. IMPORTANCE The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this study, we showed that the Bengal Bay clone emerged from a virulent progenitor circulating on the Indian subcontinent. Its subsequent global transmission was associated with travel or family contact in the region. ST772 progressively acquired specific resistance elements at limited cost to its fitness and continues to be exported globally, resulting in small-scale community and health care outbreaks. The Bengal Bay clone therefore combines the virulence potential and epidemiology of community-associated clones with the multidrug resistance of health care-associated S. aureus lineages. This study demonstrates the importance of whole-genome sequencing for the surveillance of highly antibiotic-resistant pathogens, which may emerge in the community setting of regions with poor antibiotic stewardship and rapidly spread into hospitals and communities across the world.
dc.format.extent20
dc.language.isoeng
dc.relation.ispartofmBioen
dc.rights© 2019 Steinig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.en
dc.subjectAntimicrobial resistanceen
dc.subjectBengal Bayen
dc.subjectCA-MRSAen
dc.subjectGenomic epidemiologyen
dc.subjectGlobal transmissionen
dc.subjectIndiaen
dc.subjectPhenotypingen
dc.subjectPhylodynamicsen
dc.subjectST722en
dc.subjectSouth Asiaen
dc.subjectStaphylococcus aureasen
dc.subjectWGSen
dc.subjectQH426 Geneticsen
dc.subjectQR Microbiologyen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectDASen
dc.subject.lccQH426en
dc.subject.lccQRen
dc.subject.lccRMen
dc.titleEvolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus lineage from the Indian subcontinenten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1128/mBio.01105-19
dc.description.statusPeer revieweden


This item appears in the following Collection(s)

Show simple item record