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Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
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dc.contributor.author | Vandrey, Brianna Marie | |
dc.contributor.author | Garden, Derek L.F. | |
dc.contributor.author | Ambrozova, Veronika | |
dc.contributor.author | McClure, Christina | |
dc.contributor.author | Nolan, Matthew | |
dc.contributor.author | Ainge, James Alexander | |
dc.date.accessioned | 2019-12-12T17:30:07Z | |
dc.date.available | 2019-12-12T17:30:07Z | |
dc.date.issued | 2020-01-06 | |
dc.identifier.citation | Vandrey , B M , Garden , D L F , Ambrozova , V , McClure , C , Nolan , M & Ainge , J A 2020 , ' Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory ' , Current Biology , vol. 30 , no. 1 , e5 , pp. 169-175 . https://doi.org/10.1016/j.cub.2019.11.027 | en |
dc.identifier.issn | 0960-9822 | |
dc.identifier.other | PURE: 263189949 | |
dc.identifier.other | PURE UUID: bd15ef26-6dc4-4d2d-8e0a-3bb63885801a | |
dc.identifier.other | ORCID: /0000-0002-0007-1533/work/66070516 | |
dc.identifier.other | Scopus: 85077150886 | |
dc.identifier.other | WOS: 000505692200033 | |
dc.identifier.uri | https://hdl.handle.net/10023/19127 | |
dc.description | This work was supported by a Carnegie Trust Collaborative Research Grant to J.A. and M.F.N, a Henry Dryerre scholarship from the Royal Society of Edinburgh to B.V., and grants from Wellcome Trust (200855/Z/16/Z) to M.F.N, and BBSRC (BB/M025454/1) to M.F.N. | en |
dc.description.abstract | Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents [1, 2]. The LEC is critical for integrating spatial and contextual information about objects [2, 3, 4, 5, 6]. Further, LEC neurons encode objects in the environment and the locations where objects were previously experienced and generate representations of time during the encoding and retrieval of episodes [7, 8, 9, 10, 11, 12]. However, it remains unclear how specific populations of cells within the LEC contribute to the integration of episodic memory components. Layer 2 (L2) of LEC manifests early pathology in Alzheimer’s disease (AD) and related animal models [13, 14, 15, 16]. Projections to the hippocampus from L2 of LEC arise from fan cells in a superficial sub-layer (L2a) that are immunoreactive for reelin and project to the dentate gyrus [17, 18]. Here, we establish an approach for selectively targeting fan cells using Sim1:Cre mice. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory [2, 3], we report that, after selective suppression of synaptic output from fan cells, mice can discriminate novel object-context configurations but are impaired in recognition of novel object-place-context associations. Our results suggest that memory functions are segregated between distinct LEC networks. | |
dc.language.iso | eng | |
dc.relation.ispartof | Current Biology | en |
dc.rights | Copyright © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Recognition memory | en |
dc.subject | Associative memory | en |
dc.subject | Hippocampus | en |
dc.subject | Alzheimer's | en |
dc.subject | Medial entorhinal cortex | en |
dc.subject | Object recognition | en |
dc.subject | Fan cells | en |
dc.subject | Lateral entorhinal cortex | en |
dc.subject | Episodic memory | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | DAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject.lcc | RC0321 | en |
dc.title | Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.identifier.doi | https://doi.org/10.1016/j.cub.2019.11.027 | |
dc.description.status | Peer reviewed | en |
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