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dc.contributor.authorVandrey, Brianna Marie
dc.contributor.authorGarden, Derek L.F.
dc.contributor.authorAmbrozova, Veronika
dc.contributor.authorMcClure, Christina
dc.contributor.authorNolan, Matthew
dc.contributor.authorAinge, James Alexander
dc.date.accessioned2019-12-12T17:30:07Z
dc.date.available2019-12-12T17:30:07Z
dc.date.issued2020-01-06
dc.identifier.citationVandrey , B M , Garden , D L F , Ambrozova , V , McClure , C , Nolan , M & Ainge , J A 2020 , ' Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory ' , Current Biology , vol. 30 , no. 1 , e5 , pp. 169-175 . https://doi.org/10.1016/j.cub.2019.11.027en
dc.identifier.issn0960-9822
dc.identifier.otherPURE: 263189949
dc.identifier.otherPURE UUID: bd15ef26-6dc4-4d2d-8e0a-3bb63885801a
dc.identifier.otherORCID: /0000-0002-0007-1533/work/66070516
dc.identifier.otherScopus: 85077150886
dc.identifier.otherWOS: 000505692200033
dc.identifier.urihttp://hdl.handle.net/10023/19127
dc.descriptionThis work was supported by a Carnegie Trust Collaborative Research Grant to J.A. and M.F.N, a Henry Dryerre scholarship from the Royal Society of Edinburgh to B.V., and grants from Wellcome Trust (200855/Z/16/Z) to M.F.N, and BBSRC (BB/M025454/1) to M.F.N.en
dc.description.abstractEpisodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents [1, 2]. The LEC is critical for integrating spatial and contextual information about objects [2, 3, 4, 5, 6]. Further, LEC neurons encode objects in the environment and the locations where objects were previously experienced and generate representations of time during the encoding and retrieval of episodes [7, 8, 9, 10, 11, 12]. However, it remains unclear how specific populations of cells within the LEC contribute to the integration of episodic memory components. Layer 2 (L2) of LEC manifests early pathology in Alzheimer’s disease (AD) and related animal models [13, 14, 15, 16]. Projections to the hippocampus from L2 of LEC arise from fan cells in a superficial sub-layer (L2a) that are immunoreactive for reelin and project to the dentate gyrus [17, 18]. Here, we establish an approach for selectively targeting fan cells using Sim1:Cre mice. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory [2, 3], we report that, after selective suppression of synaptic output from fan cells, mice can discriminate novel object-context configurations but are impaired in recognition of novel object-place-context associations. Our results suggest that memory functions are segregated between distinct LEC networks.
dc.language.isoeng
dc.relation.ispartofCurrent Biologyen
dc.rightsCopyright © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectRecognition memoryen
dc.subjectAssociative memoryen
dc.subjectHippocampusen
dc.subjectAlzheimer'sen
dc.subjectMedial entorhinal cortexen
dc.subjectObject recognitionen
dc.subjectFan cellsen
dc.subjectLateral entorhinal cortexen
dc.subjectEpisodic memoryen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccRC0321en
dc.titleFan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memoryen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1016/j.cub.2019.11.027
dc.description.statusPeer revieweden


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