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dc.contributor.authorBueno, R.
dc.contributor.authorHughes, E.
dc.contributor.authorWagner, S.
dc.contributor.authorGutin, A.S.
dc.contributor.authorLanchbury, J.S.
dc.contributor.authorZheng, Y.
dc.contributor.authorArcher, M.A.
dc.contributor.authorGustafson, C.
dc.contributor.authorJones, J. T.
dc.contributor.authorRushton, K.
dc.contributor.authorSaam, J.
dc.contributor.authorKim, E.
dc.contributor.authorBarberis, M.
dc.contributor.authorWistuba, I.
dc.contributor.authorWenstrup, R.J.
dc.contributor.authorWallace, W.A.
dc.contributor.authorHartman, A.-R.
dc.contributor.authorHarrison, D.J.
dc.date.accessioned2019-12-03T11:30:02Z
dc.date.available2019-12-03T11:30:02Z
dc.date.issued2015
dc.identifier159057424
dc.identifierd9e6d079-68fa-4a53-abd2-974ef0056eff
dc.identifier000346986500010
dc.identifier84926417677
dc.identifier.citationBueno , R , Hughes , E , Wagner , S , Gutin , A S , Lanchbury , J S , Zheng , Y , Archer , M A , Gustafson , C , Jones , J T , Rushton , K , Saam , J , Kim , E , Barberis , M , Wistuba , I , Wenstrup , R J , Wallace , W A , Hartman , A-R & Harrison , D J 2015 , ' Validation of a molecular and pathological model for five-year mortality risk in patients with early stage lung adenocarcinoma ' , Journal of Thoracic Oncology , vol. 10 , no. 1 , pp. 67-73 . https://doi.org/10.1097/JTO.0000000000000365en
dc.identifier.issn1556-0864
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034199
dc.identifier.urihttps://hdl.handle.net/10023/19047
dc.description.abstractIntroduction The aim of this study was to validate a molecular expression signature [cell cycle progression (CCP) score] that identifies patients with a higher risk of cancer-related death after surgical resection of early stage (I-II) lung adenocarcinoma in a large patient cohort and evaluate the effectiveness of combining CCP score and pathological stage for predicting lung cancer mortality. Methods Formalin-fixed paraffin-embedded surgical tumor samples from 650 patients diagnosed with stage I and II adenocarcinoma who underwent definitive surgical treatment without adjuvant chemotherapy were analyzed for 31 proliferation genes by quantitative real-time polymerase chain reaction. The prognostic discrimination of the expression score was assessed by Cox proportional hazards analysis using 5-year lung cancer-specific death as primary outcome. Results The CCP score was a significant predictor of lung cancer-specific mortality above clinical covariates [hazard ratio (HR) = 1.46 per interquartile range (95% confidence interval = 1.12–1.90; p = 0.0050)]. The prognostic score, a combination of CCP score and pathological stage, was a more significant indicator of lung cancer mortality risk than pathological stage in the full cohort (HR = 2.01; p = 2.8 × 10−11) and in stage I patients (HR = 1.67; p = 0.00027). Using the 85th percentile of the prognostic score as a threshold, there was a significant difference in lung cancer survival between low-risk and high-risk patient groups (p = 3.8 × 10−7). Conclusions This study validates the CCP score and the prognostic score as independent predictors of lung cancer death in patients with early stage lung adenocarcinoma treated with surgery alone. Patients with resected stage I lung adenocarcinoma and a high prognostic score may be candidates for adjuvant therapy to reduce cancer-related mortality.
dc.format.extent7
dc.format.extent639527
dc.language.isoeng
dc.relation.ispartofJournal of Thoracic Oncologyen
dc.subjectCarcinomaen
dc.subjectNonsmall cell lung canceren
dc.subjectReal-time polymerase chain reactionen
dc.subjectRisk stratificationen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectNDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject~DC~en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0254en
dc.titleValidation of a molecular and pathological model for five-year mortality risk in patients with early stage lung adenocarcinomaen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1097/JTO.0000000000000365
dc.description.statusPeer revieweden


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