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dc.contributor.advisorFlorence, Gordon John
dc.contributor.advisorGunn-Moore, Frank J.
dc.contributor.authorAbdul Razzak, Rana
dc.coverage.spatial225 p.en_US
dc.description.abstractNanoparticles (NPs) have emerged as a promising approach to overcoming biological barriers imposed by the human body. Polymeric NPs offer a superior synthetic flexibility and advances in polymerization chemistries have made polymeric architectures with precisely tuned properties accessible. Ring opening metathesis polymerization (ROMP) has become a popular polymerization technique due to its mild conditions a tolerance to an array of functional groups. We successfully synthesized two generations of ROMP monomers that feature polymerizable group and a mitochondrial targeting ligand linked together via a hydrophilic spacer. This monomer can be co-polymerized with another ROMP monomer bearing a fluorescent molecule to enable the visualization of the polymeric NPs in the cell. The second-generation monomers differ from the first-generation analogues by their three-fold longer hydrophilic linkers. Co-polymers prepared from second-generation monomers show cellular up-take but no mitochondrial localization.en_US
dc.publisherUniversity of St Andrews
dc.titleTowards mitochondrial targeting for the treatment of Alzheimer's Diseaseen_US
dc.contributor.sponsorUniversity of St Andrewsen_US
dc.contributor.sponsorSt Andrews Education for Palestinian Students (STEPS)en_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US
dc.rights.embargoreasonThesis restricted in accordance with University regulations. Print and electronic copy restricted until 10th April 2024en

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