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A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila
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dc.contributor.author | Babski, H. | |
dc.contributor.author | Jovanic, T. | |
dc.contributor.author | Surel, C. | |
dc.contributor.author | Yoshikawa, S. | |
dc.contributor.author | Zwart, M. F. | |
dc.contributor.author | Valmier, J. | |
dc.contributor.author | Thomas, J. B. | |
dc.contributor.author | Enriquez, J. | |
dc.contributor.author | Carroll, P. | |
dc.contributor.author | Garcès, A. | |
dc.date.accessioned | 2019-10-31T16:30:11Z | |
dc.date.available | 2019-10-31T16:30:11Z | |
dc.date.issued | 2019-10-22 | |
dc.identifier | 262577022 | |
dc.identifier | 4fc0f60b-4140-4ca0-bc24-14b5899d11d8 | |
dc.identifier | 85073731880 | |
dc.identifier | 31641138 | |
dc.identifier | 000491306200004 | |
dc.identifier.citation | Babski , H , Jovanic , T , Surel , C , Yoshikawa , S , Zwart , M F , Valmier , J , Thomas , J B , Enriquez , J , Carroll , P & Garcès , A 2019 , ' A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila ' , Nature Communications , vol. 10 , 4796 . https://doi.org/10.1038/s41467-019-12693-6 | en |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | ORCID: /0000-0002-5073-8631/work/64034752 | |
dc.identifier.uri | https://hdl.handle.net/10023/18812 | |
dc.description | This work was funded by grants from INSERM and a 3-year Ph.D. funding from the Association Française contre les Myopathies (AFM) for H.B (Doctoral funding n°19408) and from ANR (17-CE37-0019) for T.J. | en |
dc.description.abstract | Interneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other animals, limiting our understanding of the principles underlying neuronal circuit organization and function. Here we characterize a restricted subset of neurons in the nerve cord expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ+ neurons are highly diverse and selective activation of these different subtypes disrupts larval body posture and induces specific locomotor behaviors. Finally, we show that a small subset of TJ+ GABAergic INs, singled out by the expression of a unique transcription factors code, controls larval crawling speed. | |
dc.format.extent | 17 | |
dc.format.extent | 7070184 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Communications | en |
dc.subject | QH301 Biology | en |
dc.subject | Chemistry(all) | en |
dc.subject | Biochemistry, Genetics and Molecular Biology(all) | en |
dc.subject | Physics and Astronomy(all) | en |
dc.subject | NDAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject.lcc | QH301 | en |
dc.title | A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | 10.1038/s41467-019-12693-6 | |
dc.description.status | Peer reviewed | en |
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