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Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

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Lian_etal_npjFlexibleElectronics3_Flexible_organic_CC.pdf (1.334Mb)
Date
18/09/2019
Author
Lian, Cheng
Piksa, Marta
Yoshida, Kou
Persheyev, Saydulla
Pawlik, Krzysztof
Matczyszyn, Katarzyna
Samuel, Ifor David William
Keywords
Organic light-emitting diodes (OLEDs)
Antimicrobial photodynamic therapy (aPDT)
Flexible electronics
Methylene blue
QC Physics
DAS
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Abstract
Bacterial infection is a serious and growing problem as antibiotic resistance grows leading to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting flexible OLEDs with the ability to tune the emission peak from 669-737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelflife. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED-PDT for killing S. aureus was performed. The results show that our OLEDs in combination with the photosensitizer methylene blue can kill more than 99% of bacteria, which indicates a huge potential for using OLEDs to treat bacterial infections.
Citation
Lian , C , Piksa , M , Yoshida , K , Persheyev , S , Pawlik , K , Matczyszyn , K & Samuel , I D W 2019 , ' Flexible organic light-emitting diodes for antimicrobial photodynamic therapy ' , npj Flexible Electronics , vol. 3 , 18 . https://doi.org/10.1038/s41528-019-0058-0
Publication
npj Flexible Electronics
Status
Peer reviewed
DOI
https://doi.org/10.1038/s41528-019-0058-0
ISSN
2397-4621
Type
Journal article
Rights
Copyright © The Author(s) 2019 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Description
The authors are grateful to the European Research Council (grant 321305) and EPSRC (grant EP/L015110/1) for financial support. The authors would like to acknowledge EU grant Polythea (grant 764837) as well as support from the Polish Ministry of Science and Higher Education for the Faculty of Chemistry of WUT.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/18793

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