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dc.contributor.authorRobinson, Kelly J.
dc.contributor.authorHall, Ailsa J.
dc.contributor.authorDebier, Cathy
dc.contributor.authorEppe, Gauthier
dc.contributor.authorThomé, Jean Pierre
dc.contributor.authorBennett, Kimberley A.
dc.date.accessioned2019-10-18T23:36:59Z
dc.date.available2019-10-18T23:36:59Z
dc.date.issued2018-11-20
dc.identifier256682680
dc.identifier4d8dd0dd-92f7-4443-a401-1eb7700a5300
dc.identifier85056421537
dc.identifier000451245700061
dc.identifier.citationRobinson , K J , Hall , A J , Debier , C , Eppe , G , Thomé , J P & Bennett , K A 2018 , ' Persistent organic pollutant burden, experimental POP exposure, and tissue properties affect metabolic profiles of blubber from gray seal pups ' , Environmental Science and Technology , vol. 52 , no. 22 , pp. 13523-13534 . https://doi.org/10.1021/acs.est.8b04240en
dc.identifier.issn0013-936X
dc.identifier.otherORCID: /0000-0002-7562-1771/work/51010290
dc.identifier.otherORCID: /0000-0002-6212-9710/work/75996845
dc.identifier.urihttps://hdl.handle.net/10023/18712
dc.descriptionThe long term program of research on grey seals at the Isle of May was funded by the SMRU national capability grant (SMRU 1001). K.A.B. was funded by NERC grant NE/M013723/1 and A.J.H. and K.J.R. were funded by NE/M01357X/1 for this project.en
dc.description.abstractPersistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue, and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but consequences for their tissue metabolic characteristics are unknown. We used blubber explants from wild, gray seal (Halichoerus grypus) pups to examine impacts of intrinsic tissue POP burden and acute experimental POP exposure on adipose metabolic characteristics. Glucose use, lactate production, and lipolytic rate differed between matched inner and outer blubber explants from the same individuals and between feeding and natural fasting. Glucose use decreased with blubber dioxin-like PCBs (DL-PCB) and increased with acute experimental POP exposure. Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilization are vital. Such POP-induced alterations to adipose metabolic properties may significantly alter energy balance regulation in marine top predators, with the potential for long-term impacts on fitness and survival.
dc.format.extent1165531
dc.language.isoeng
dc.relation.ispartofEnvironmental Science and Technologyen
dc.subjectDioxin-like PCBSen
dc.subjectGlucose uptakeen
dc.subjectLipolysisen
dc.subjectLactate productionen
dc.subjectBlubber depthen
dc.subjectEnergetic stateen
dc.subjectEnvironmental contaminationen
dc.subjectFastingen
dc.subjectFeedingen
dc.subjectQH301 Biologyen
dc.subjectChemistry(all)en
dc.subjectEnvironmental Chemistryen
dc.subjectNDASen
dc.subjectNERCen
dc.subjectSDG 14 - Life Below Wateren
dc.subject.lccQH301en
dc.titlePersistent organic pollutant burden, experimental POP exposure, and tissue properties affect metabolic profiles of blubber from gray seal pupsen
dc.typeJournal articleen
dc.contributor.sponsorNERCen
dc.contributor.sponsorNERCen
dc.contributor.institutionUniversity of St Andrews. Sea Mammal Research Uniten
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.identifier.doihttps://doi.org/10.1021/acs.est.8b04240
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-10-19
dc.identifier.grantnumberen
dc.identifier.grantnumberNE/M01357X/1en


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