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dc.contributor.authorBrookes, K
dc.contributor.authorHawi, Ziarah
dc.contributor.authorPark, J
dc.contributor.authorScott, S
dc.contributor.authorGill, M
dc.contributor.authorKent, Lindsey
dc.date.accessioned2011-06-16T15:32:13Z
dc.date.available2011-06-16T15:32:13Z
dc.date.issued2010-12
dc.identifier.citationBrookes , K , Hawi , Z , Park , J , Scott , S , Gill , M & Kent , L 2010 , ' Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression ' American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics , vol 153B , no. 8 , pp. 1417-1424 . DOI: 10.1002/ajmg.b.31120en
dc.identifier.issn1552-4841
dc.identifier.otherPURE: 2340937
dc.identifier.otherPURE UUID: acb5465d-afd3-4548-8958-f2dee5055ef3
dc.identifier.otherScopus: 78851469712
dc.identifier.otherWOS: 000284623200005
dc.identifier.urihttp://hdl.handle.net/10023/1867
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=78851469712&partnerID=8YFLogxKen
dc.descriptionSupported by Wellcome Trust fundingen
dc.description.abstractPrevious studies in animals and humans have implicated the X-chromosome STS gene in the etiology of attentional difficulties and attention deficit hyperactivity disorder (ADHD). This family based association study has fine mapped a region of the STS gene across intron 1 and 2 previously associated with ADHD, in an extended sample of 450 ADHD probands and their parents. Significant association across this region is demonstrated individually with 7 of the 12 genotyped SNPs, as well as an allele specific haplotype of the 12 SNPs. The over transmitted risk allele of rs12861247 was also associated with reduced STS mRNA expression in normal human post-mortem frontal cortex brain tissue compared to the non-risk allele (P = 0.01). These results are consistent with the hypothesis arising from previous literature demonstrating that boys with deletions of the STS gene, and hence no STS protein are at a significantly increased risk of developing ADHD. Furthermore, this study has established the brain tissue transcript of STS, which except from adipose tissue, differs from that seen in all other tissues investigated. © 2010 Wiley-Liss, Inc.en
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Medical Genetics. Part B, Neuropsychiatric Geneticsen
dc.rights(c) 2010 Wiley-Liss, Inc. Online Open article, deposited according to publisher policy. Also available from DOI: 10.1002/ajmg.b.31120en
dc.subjectSteroid sulfataseen
dc.subjectADHDen
dc.subjectAssociation studyen
dc.subjectHuman brain tissueen
dc.subjectmRNAen
dc.subjectRB Pathologyen
dc.subject.lccRBen
dc.titlePolymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expressionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttp://dx.doi.org/10.1002/ajmg.b.31120
dc.description.statusPeer revieweden


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