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Active natural product scaffolds against trypanosomatid parasites : a review
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dc.contributor.author | Cockram, Peter E. | |
dc.contributor.author | Smith, Terry K. | |
dc.date.accessioned | 2019-09-19T23:37:34Z | |
dc.date.available | 2019-09-19T23:37:34Z | |
dc.date.issued | 2018-09-28 | |
dc.identifier.citation | Cockram , P E & Smith , T K 2018 , ' Active natural product scaffolds against trypanosomatid parasites : a review ' , Journal of Natural Products , vol. 81 , no. 9 , pp. 2138-2154 . https://doi.org/10.1021/acs.jnatprod.8b00159 | en |
dc.identifier.issn | 0163-3864 | |
dc.identifier.other | PURE: 256161989 | |
dc.identifier.other | PURE UUID: 0722ea59-16db-483c-afd7-9d5d9992b5cd | |
dc.identifier.other | Scopus: 85053885429 | |
dc.identifier.other | WOS: 000446276600031 | |
dc.identifier.uri | https://hdl.handle.net/10023/18523 | |
dc.description | This work was supported through funding from the EPSRC and the School of Chemistry (University of St Andrews). | en |
dc.description.abstract | Neglected tropical diseases caused by trypanosomatid parasites are a continuing and escalating problem, which devastate the less economically developed cultures in countries in which they are endemic by impairing both human and animal health. Current drugs for these diseases are regarded as out-of-date and expensive, with unacceptable side-effects and mounting parasite resistance, meaning there is an urgent need for new therapeutics. Natural products have long been a source of potent, structurally diverse bioactive molecules. Herein are reviewed natural products with reported trypanocidal activity, which have been clustered based on core structural similarities, to aid the future discovery of new trypanocidal core motifs with potential routes to synthetically accessible natural product cores suggested. | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Natural Products | en |
dc.rights | © 2018, American Chemical Society and American Society of Pharmacognosy. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1021/acs.jnatprod.8b00159 | en |
dc.subject | QD Chemistry | en |
dc.subject | QH301 Biology | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | Molecular Medicine | en |
dc.subject | Analytical Chemistry | en |
dc.subject | Organic Chemistry | en |
dc.subject | Complementary and alternative medicine | en |
dc.subject | Drug Discovery | en |
dc.subject | Pharmaceutical Science | en |
dc.subject | Pharmacology | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QD | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RM | en |
dc.title | Active natural product scaffolds against trypanosomatid parasites : a review | en |
dc.type | Journal item | en |
dc.contributor.sponsor | EPSRC | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1021/acs.jnatprod.8b00159 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2019-09-20 | |
dc.identifier.grantnumber | EP/P511043/1 | en |
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