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dc.contributor.authorGuha, Nitul
dc.contributor.authorNeyya Ppadath, Rifahath Mon
dc.contributor.authorGreenhalgh, Mark
dc.contributor.authorChisholm, Ross
dc.contributor.authorSmith, Samuel
dc.contributor.authorMcEvoy, Megan
dc.contributor.authorRodríguez-Escrich, Carles
dc.contributor.authorYoung, Claire M.
dc.contributor.authorPericas, Miquel A.
dc.contributor.authorHähner, Georg
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2019-08-22T23:44:14Z
dc.date.available2019-08-22T23:44:14Z
dc.date.issued2018-08-24
dc.identifier.citationGuha , N , Neyya Ppadath , R M , Greenhalgh , M , Chisholm , R , Smith , S , McEvoy , M , Rodríguez-Escrich , C , Young , C M , Pericas , M A , Hähner , G & Smith , A D 2018 , ' Evaluating polymer-supported isothiourea catalysis in industrially-preferable solvents for the acylative kinetic resolution of secondary and tertiary heterocyclic alcohols in batch and flow ' , Green Chemistry , vol. In press . https://doi.org/10.1039/C8GC02020Een
dc.identifier.issn1463-9262
dc.identifier.otherPURE: 255537882
dc.identifier.otherPURE UUID: 7d05db4f-6b53-459b-a849-91ad1f9da461
dc.identifier.otherScopus: 85054497937
dc.identifier.otherORCID: /0000-0002-2104-7313/work/47725764
dc.identifier.otherORCID: /0000-0002-6765-344X/work/60426714
dc.identifier.otherWOS: 000448411200020
dc.identifier.urihttps://hdl.handle.net/10023/18357
dc.descriptionThe authors thank the Royal Society and the Science and Engineering Board of India (SERB) for the award of a Royal Society-SERB Newton International Fellowship (N.R.G.). The authors also thank the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT, grant code EP/L016419/1, R.M.N.P.) for funding. Financial support from the EPSRC (EP/K000411/1) is gratefully acknowledged (R.C.). The authors thank the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) ERC grant agreement no. 279850 (A.D.S). A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. C.R.-E. and M.A.P. acknowledge the financial support from CERCA Programme/Generalitat de Catalunya, MINECO (CTQ2015-69136-R, AEI/MINECO/FEDER, UE and Severo Ochoa Excellence Accreditation 2014–2018, SEV-2013-0319) and DEC Generalitat de Catalunya (Grant 2014SGR827).en
dc.description.abstractPolymer-supported Lewis base catalysts, based on the homogeneous isothioureas HyperBTM and BTM, have been synthesised and applied for the acylative kinetic resolution of secondary and tertiary heterocyclic alcohols. In batch, the use of industrially-preferable solvents was investigated, with dimethyl carbonate proving to be most generally-applicable. Significantly, the HyperBTM-derived immobilised catalysts were readily recycled, with no loss in either activity or selectivity. In addition to the kinetic resolution of secondary benzylic, propargylic, allylic and cycloalkanol derivatives, a range of 21 tertiary heterocyclic alcohols, based on privileged 3-hydroxyoxindole and 3-hydroxypyrrolidinone substructures, were resolved with up to excellent selectivity (s = 7–190). Finally, the immobilised isothiourea catalysts were applied in a packed bed reactor to demonstrate the first example of the kinetic resolution of tertiary heterocyclic alcohols in a continuous flow process. High selectivities were obtained for the resolution of 3-hydroxyoxindole derivatives in ethyl acetate (s up to 70); and for 3-hydroxypyrrolidinones derivatives in toluene (s up to 42).
dc.language.isoeng
dc.relation.ispartofGreen Chemistryen
dc.rights© 2018 the Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/ 10.1039/C8GC02020Een
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleEvaluating polymer-supported isothiourea catalysis in industrially-preferable solvents for the acylative kinetic resolution of secondary and tertiary heterocyclic alcohols in batch and flowen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1039/C8GC02020E
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-08-23
dc.identifier.grantnumberEP/L016419/1en
dc.identifier.grantnumberep/k000411/1en
dc.identifier.grantnumberN/Aen
dc.identifier.grantnumberWM140071en


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