Six 1-aroyl-4-(4-methoxyphenyl)piperazines : similar molecular structures but different patterns of supramolecular assembly
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08/2019Author
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Abstract
Six new 1-aroyl-4-(4-methoxyphenyl)piperazines have been prepared, using coupling reactions between benzoic acids and N-(4-methoxyphenyl)piperazine. There are no significant hydrogen bonds in the structure of 1-benzoyl-4-(4-methoxyphenyl)piperazine, C18H20N2O2, (I). The molecules of 1-(2-fluorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19FN2O2, (II), are linked by two C—H⋯O hydrogen bonds to form chains of rings, which are linked into sheets by an aromatic π–π stacking interaction. 1-(2-Chlorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19ClN2O2, (III), 1-(2-bromobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19BrN2O2, (IV), and 1-(2-iodobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19IN2O2, (V), are isomorphous, but in (III) the aroyl ring is disordered over two sets of atomic sites having occupancies of 0.942 (2) and 0.058 (2). In each of (III)–(V), a combination of two C—H⋯π(arene) hydrogen bonds links the molecules into sheets. A single O—H⋯O hydrogen bond links the molecules of 1-(2-hydroxybenzoyl)-4-(4-methoxyphenyl)piperazine, C18H20N2O3, (VI), into simple chains. Comparisons are made with the structures of some related compounds.
Citation
Kiran Kumar , H , Yathirajan , H S , Sagar , B K , Foro , S & Glidewell , C 2019 , ' Six 1-aroyl-4-(4-methoxyphenyl)piperazines : similar molecular structures but different patterns of supramolecular assembly ' , Acta Crystallographica Section E , vol. 75 , no. 8 , pp. 1253-1260 . https://doi.org/10.1107/S2056989019010491
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Acta Crystallographica Section E
Status
Peer reviewed
ISSN
2056-9890Type
Journal article
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Copyright © 2019 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
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HSY thanks the University Grants Commission, New Delhi, for the award of a BSR Faculty Fellowship for three years.Collections
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