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dc.contributor.authorRichardson, Marty
dc.contributor.authorKirkham, Jamie J.
dc.contributor.authorDwan, Kerry M.
dc.contributor.authorSloan, Derek J.
dc.contributor.authorDavies, Geraint
dc.contributor.authorJorgensen, Andrea
dc.date.accessioned2019-08-09T12:30:02Z
dc.date.available2019-08-09T12:30:02Z
dc.date.issued2019-07-11
dc.identifier.citationRichardson , M , Kirkham , J J , Dwan , K M , Sloan , D J , Davies , G & Jorgensen , A 2019 , ' Protocol for the development of the STrengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline : checklist of items for reporting pharmacogenetic studies ' , BMJ Open , vol. 9 , no. 7 , e030212 . https://doi.org/10.1136/bmjopen-2019-030212en
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 260484510
dc.identifier.otherPURE UUID: 1178712d-e312-4395-8cfa-77692e33e1ba
dc.identifier.otherScopus: 85069483047
dc.identifier.otherPubMed: 31300508
dc.identifier.urihttp://hdl.handle.net/10023/18285
dc.descriptionMR is supported partly by Liverpool Reviews and Implementation Group (LRiG, based at the University of Liverpool), based on funding from the National Institute for Health Research Health Technology Assessment Programme (URL, http://www.nets.nihr.ac.uk/programmes/hta), and partly by the Research, Evidence and Development Initiative (READ-It) project. READ-It (project number 300342-104) is funded by UK aid from the UK government.en
dc.description.abstractIntroduction: Large sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesise data from several studies, increasing sample size and consequently power to detect significant genetic effects. However, performing robust synthesis of data from pharmacogenetic studies is often challenging due to poor reporting of key data in study reports. There is currently no guideline for the reporting of pharmacogenetic studies. The aim of this project is to develop the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline. The STROPS guideline will facilitate the conduct of high-quality meta-analyses and thus improve the power to detect genetic associations. Methods and analysis:  We will establish a preliminary checklist of reporting items to be considered for inclusion in the guideline. We will then conduct a Delphi survey of key stakeholder groups to gain consensus opinion on which reporting items to include in the final guideline. The Delphi survey will consist of two rounds: the first round will invite participants to score items from the preliminary checklist and to suggest additional relevant items; the second round will provide feedback from the previous round and invite participants to re-score the items. Following the second round, we will summarise the distribution of scores for each item, stratified by stakeholder group. The Steering Committee for the project and representatives from the key stakeholder groups will meet to consider the results of the Delphi survey and to finalise the list of reporting items. We will then draft, pilot-test and publish the STROPS reporting guideline and accompanying explanatory document. Ethics and dissemination: The University of Liverpool Ethics Committee has confirmed ethical approval for this study (reference: 3586). Dissemination activities will include presenting the reporting guideline at conferences relevant to pharmacogenetic research.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofBMJ Openen
dc.rightsCopyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.en
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectMedicine(all)en
dc.subjectT-NDASen
dc.subject.lccRA0421en
dc.titleProtocol for the development of the STrengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline : checklist of items for reporting pharmacogenetic studiesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2019-030212
dc.description.statusPeer revieweden


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