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dc.contributor.authorAhmadpour, Ehsan
dc.contributor.authorForoutan-Rad, Masoud
dc.contributor.authorMajidiani, Hamidreza
dc.contributor.authorMoghaddam, Sirous Mehrani
dc.contributor.authorHatam-Nahavandi, Kareem
dc.contributor.authorHosseini, Seyed-Abdollah
dc.contributor.authorRahimi, Mohammad Taghi
dc.contributor.authorBarac, Aleksandra
dc.contributor.authorRubino, Salvatore
dc.contributor.authorZarean, Mehdi
dc.contributor.authorMathioudakis, Alexander G
dc.contributor.authorCevik, Muge
dc.identifier.citationAhmadpour , E , Foroutan-Rad , M , Majidiani , H , Moghaddam , S M , Hatam-Nahavandi , K , Hosseini , S-A , Rahimi , M T , Barac , A , Rubino , S , Zarean , M , Mathioudakis , A G & Cevik , M 2019 , ' Transfusion-transmitted malaria : a systematic review and meta-analysis ' , Open Forum Infectious Diseases , vol. 6 , no. 7 , ofz283 .
dc.identifier.otherPURE: 260335129
dc.identifier.otherPURE UUID: 046992a0-ed06-4d39-96c5-af6dfc2b0368
dc.identifier.otherPubMed: 31334300
dc.identifier.otherPubMedCentral: PMC6634438
dc.identifier.otherORCID: /0000-0003-1133-3874/work/60427709
dc.identifier.otherScopus: 85073259703
dc.identifier.otherWOS: 000481501400032
dc.description.abstractBackground : Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature. Methods : PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran's Q test. Publication and population bias was assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2). Results : Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum. Conclusions : This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.
dc.relation.ispartofOpen Forum Infectious Diseasesen
dc.rights© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.subjectBlood donoren
dc.subjectSystematic reviewen
dc.subjectTransfusion-associated infectionsen
dc.subjectTransfusion medicineen
dc.subjectQR180 Immunologyen
dc.titleTransfusion-transmitted malaria : a systematic review and meta-analysisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.description.statusPeer revieweden

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