The University of St Andrews

Research@StAndrews:FullText >
Medicine (School of) >
Medicine >
Medicine Research >

Please use this identifier to cite or link to this item:
View Statistics

Files in This Item:

File Description SizeFormat
GHSharwoodSmithCoverSheet2.pdf100.68 kBAdobe PDFView/Open
Title: Ephedrine requirements are reduced during spinal anaesthesia for caesarean section in preeclampsia
Authors: Clark, V. A.
Sharwood-Smith, Geoffrey H.
Stewart, A. V. G.
Keywords: Anaesthesia
Obstetric anaesthesia
Spinal anaesthesia
Issue Date: Jan-2005
Citation: Clark, V.A., Sharwood-Smith, G.H. and Stewart, A.V.G. 2005. Ephedrine requirements are reduced during spinal anaesthesia for caesarean section in preeclampsia. International Journal of Obstetric Anesthesia. 14(1): 9-13
Abstract: Background: Despite controversy over the haemodynamically safest blockade for caesarean section in women with severe preeclampsia, an increasing number of anaesthetists now opt for spinal anaesthesia. In a previous study we found that spinal compared to epidural anaesthesia offered an equally safe but more effective option for these patients. The current study was designed to compare the hypotension induced by spinal anaesthesia, as measured by ephedrine requirement, between 20 normotensive and 20 severely preeclamptic but haemodynamically stabilised women. Method: Standardised spinal anaesthesia was instituted and ephedrine was given in boluses of 6 mg if the systolic pressure fell >20% from the baseline, or if the patient exhibited symptoms of hypotension. Results: The mean ephedrine requirement of the normotensive group (27.9 ± 11.6 mg) was significantly greater (P < 0.01) than that of the preeclamptic group (16.4 ± 15.0 mg). Conclusion: This suggests that the hypotension induced by spinal anaesthesia in women with severe but haemodynamically stabilised preeclampsia, is less than that of normotensive patients.
Version: Publisher PDF
Description: Part of the Portfolio Thesis by Geoffrey H. Sharwood-Smith: The inferior vena caval compression theory of hypotension in obstetric spinal anaesthesia: studies in normal and preeclamptic pregnancy, a literature review and revision of fundamental concepts, available at
ISSN: 0959-289X
Type: Journal article
Rights: Copyright (c)2004 Elsevier Ltd. Deposited as part of portfolio thesis by permission of the publisher.
Publication Status: Published
Status: Peer reviewed
Publisher: Elsevier Ltd.
Appears in Collections:Medicine Research

This item is protected by original copyright

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


DSpace Software Copyright © 2002-2012  Duraspace - Feedback
For help contact: | Copyright for this page belongs to St Andrews University Library | Terms and Conditions (Cookies)