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dc.contributor.authorMoon, Won Young
dc.contributor.authorPowis, Simon J.
dc.identifier.citationMoon , W Y & Powis , S J 2019 , ' Does natural killer cell deficiency (NKD) increase the risk of cancer? NKD may increase the risk of some virus induced cancer ' , Frontiers in Immunology , vol. 10 , 1703 .
dc.identifier.otherPURE: 260273816
dc.identifier.otherPURE UUID: 523dd958-b44e-4fdf-9457-4748bba1512c
dc.identifier.otherBibtex: urn:7b4da88c791ab0d0f1a23ccd2a283d80
dc.identifier.otherWOS: 000476744500001
dc.identifier.otherScopus: 85071160646
dc.description.abstractNatural killer cell deficiency (NKD) is a primary immunodeficiency where the main defect lies in CD56+CD3− natural killer (NK) cells which mediate cytotoxicity against tumors. Most cases are observed in children and adolescents with recurrent viral infections and cancer. GATA2 and MCM4 mutations are found in NKD patients with cancer. However, the question remains unclear whether NKD increases the risk of cancer. Mutations in the second zinc finger of GATA2 cause both NKD and haematopoietic malignancies. MCM4 splice site mutations are found in NKD patients and they increase susceptibility to DNA instability during replication. IRF8, RTEL1, and FCGR3A mutations are associated with NKD but their associations with cancer are unknown. Based on the studies, it is hypothesized that genetic mutations alone are sufficient to cause cancer. However, a number of NKD patients developed oncogenic viral infections which progressed into cancer. Here, we review the evidence of genetic mutations responsible for both NKD and cancer to identify whether NKD contributes to development of cancer. The findings provide insights into the role of NK cells in the prevention of cancer and the significance of assessing NK cell functions in susceptible individuals.
dc.relation.ispartofFrontiers in Immunologyen
dc.rightsCopyright © 2019 Moon and Powis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectNK cellsen
dc.subjectOncogenic viral infectionsen
dc.subjectCD56bright NK cellsen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQR180 Immunologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleDoes natural killer cell deficiency (NKD) increase the risk of cancer? NKD may increase the risk of some virus induced canceren
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.description.statusPeer revieweden

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