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dc.contributor.authorKochayoo, Piyawan
dc.contributor.authorKittisenachai, Natthapon
dc.contributor.authorChangrob, Siriruk
dc.contributor.authorWangriatisak, Kittikorn
dc.contributor.authorMuh, Fauzi
dc.contributor.authorChootong, Patchanee
dc.contributor.authorHan, Eun-Taek
dc.date.accessioned2019-07-17T16:30:05Z
dc.date.available2019-07-17T16:30:05Z
dc.date.issued2019-05-31
dc.identifier.citationKochayoo , P , Kittisenachai , N , Changrob , S , Wangriatisak , K , Muh , F , Chootong , P & Han , E-T 2019 , ' The acquisition of long-lived memory B cell responses to merozoite surface protein-8 in individuals with Plasmodium vivax infection ' , Malaria Journal , vol. 18 , 188 . https://doi.org/10.1186/s12936-019-2821-zen
dc.identifier.issn1475-2875
dc.identifier.otherPURE: 259651700
dc.identifier.otherPURE UUID: 0b54e9c1-e12a-4959-9ca9-f56a500ee386
dc.identifier.otherWOS: 000469761100001
dc.identifier.otherScopus: 85066627769
dc.identifier.otherORCID: /0000-0002-3966-9110/work/59698775
dc.identifier.urihttp://hdl.handle.net/10023/18117
dc.description.abstractBackground : The ability of a malaria antigen to induce effective, long-lasting immune responses is important for the development of a protective malaria vaccine. Plasmodium vivax merozoite surface protein-8 (PvMSP8) has been shown to be immunogenic in natural P. vivax infections and produces both cell-mediated and antibody-mediated immunity. Thus, PvMSP8 has been proposed as a vaccine candidate following fusion with other merozoite antigens in blood stage vaccine design. Here, the long-term responses of antibodies and memory B cells (MBCs) specific to PvMSP8 in individuals were monitored in a longitudinal cohort study. Methods : Both cross-sectional surveys and cohort studies were utilized to explore the persistence of antibody and MBC responses to PvMSP8. Antibody titers were detected in individuals with acute disease and those who recovered from an infection for 4 years. The dominant peptide epitope of PvMSP8 recognized by naturally acquired antibodies was examined to observe the durability of the post-infection antibody response. PvMSP8-specific MBCs were also in subjects 4 years post-infection using an enzyme-linked immunospot assay. Results : The prevalence of antibodies to PvMSP8 was high during and after infection. The antibody levels in individual responders were monitored for up to 12 months post-infection and showed that most patients maintained their seropositive response. Interestingly, the anti-PvMSP8 antibody responses stably persisted in some patients who had recovered from an infection for 4 years. Positive PvMSP8-specific MBCs were also detected at 4 years post-infection. However, analysis in these individuals showed no correlation with the presence or titer of circulating antibody. Conclusion : PvMSP8 had the ability to induce a long-term humoral immune response. The antibodies and MBCs specific for this antigen developed and persisted in subjects who acquired a natural P. vivax infection. Inclusion of the PvMSP8 antigen in blood stage vaccine design should be considered.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofMalaria Journalen
dc.rights© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creat iveco mmons .org/publi cdoma in/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectPlasmodium vivaxen
dc.subjectMerozoite surface protein 8en
dc.subjectMemory B cellsen
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectQR180 Immunologyen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.subject.lccQR180en
dc.titleThe acquisition of long-lived memory B cell responses to merozoite surface protein-8 in individuals with Plasmodium vivax infectionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1186/s12936-019-2821-z
dc.description.statusPeer revieweden


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