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Vaccine and antibody production in plants : developments and computational tools
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dc.contributor.author | Dubey, Kashyap Kumar | |
dc.contributor.author | Luke, Garry A. | |
dc.contributor.author | Knox, Caroline | |
dc.contributor.author | Kumar, Punit | |
dc.contributor.author | Pletschke, Brett I. | |
dc.contributor.author | Singh, Puneet Kumar | |
dc.contributor.author | Shukla, Pratyoosh | |
dc.date.accessioned | 2019-07-04T23:40:35Z | |
dc.date.available | 2019-07-04T23:40:35Z | |
dc.date.issued | 2018-09 | |
dc.identifier | 254170917 | |
dc.identifier | 3ab20569-e6d3-4c73-bfca-1ee55a12f8bf | |
dc.identifier | 85060750042 | |
dc.identifier.citation | Dubey , K K , Luke , G A , Knox , C , Kumar , P , Pletschke , B I , Singh , P K & Shukla , P 2018 , ' Vaccine and antibody production in plants : developments and computational tools ' , Briefings in Functional Genomics , vol. 17 , no. 5 , pp. 295-307 . https://doi.org/10.1093/bfgp/ely020 | en |
dc.identifier.issn | 2041-2649 | |
dc.identifier.uri | https://hdl.handle.net/10023/18045 | |
dc.description | K.K.D. and P.S. sincerely acknowledge the support and facility provided by the M.D. University, Rohtak, Haryana. P.S. acknowledges the infrastructural support from Department of Science and Technology, Govt. of India through FIST grant (Grant No. 1196 SR/FST/LS-I/2017/4). | en |
dc.description.abstract | Plants as bioreactors have been widely used to express efficient vaccine antigens against viral, bacterial and protozoan infections. To date, many different plant-based expression systems have been analyzed, with a growing preference for transient expression systems. Antibody expression in diverse plant species for therapeutic applications is well known, and this review provides an overview of various aspects of plant-based biopharmaceutical production. Here, we highlight conventional and gene expression technologies in plants along with some illustrative examples. In addition, the portfolio of products that are being produced and how they relate to the success of this field are discussed. Stable and transient gene expression in plants, agrofiltration and virus infection vectors are also reviewed. Further, the present report draws attention to antibody epitope prediction using computational tools, one of the crucial steps of vaccine design. Finally, regulatory issues, biosafety and public perception of this technology are also discussed. | |
dc.format.extent | 14 | |
dc.format.extent | 1066303 | |
dc.language.iso | eng | |
dc.relation.ispartof | Briefings in Functional Genomics | en |
dc.subject | Epitope prediction | en |
dc.subject | Computational tools | en |
dc.subject | Genetic engineering | en |
dc.subject | Plantibody | en |
dc.subject | Edible vaccine | en |
dc.subject | QH301 Biology | en |
dc.subject | QH426 Genetics | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | QH426 | en |
dc.title | Vaccine and antibody production in plants : developments and computational tools | en |
dc.type | Journal item | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1093/bfgp/ely020 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2019-07-05 |
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