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dc.contributor.authorDubey, Kashyap Kumar
dc.contributor.authorLuke, Garry A.
dc.contributor.authorKnox, Caroline
dc.contributor.authorKumar, Punit
dc.contributor.authorPletschke, Brett I.
dc.contributor.authorSingh, Puneet Kumar
dc.contributor.authorShukla, Pratyoosh
dc.identifier.citationDubey , K K , Luke , G A , Knox , C , Kumar , P , Pletschke , B I , Singh , P K & Shukla , P 2018 , ' Vaccine and antibody production in plants : developments and computational tools ' , Briefings in Functional Genomics , vol. 17 , no. 5 , pp. 295-307 .
dc.descriptionK.K.D. and P.S. sincerely acknowledge the support and facility provided by the M.D. University, Rohtak, Haryana. P.S. acknowledges the infrastructural support from Department of Science and Technology, Govt. of India through FIST grant (Grant No. 1196 SR/FST/LS-I/2017/4).en
dc.description.abstractPlants as bioreactors have been widely used to express efficient vaccine antigens against viral, bacterial and protozoan infections. To date, many different plant-based expression systems have been analyzed, with a growing preference for transient expression systems. Antibody expression in diverse plant species for therapeutic applications is well known, and this review provides an overview of various aspects of plant-based biopharmaceutical production. Here, we highlight conventional and gene expression technologies in plants along with some illustrative examples. In addition, the portfolio of products that are being produced and how they relate to the success of this field are discussed. Stable and transient gene expression in plants, agrofiltration and virus infection vectors are also reviewed. Further, the present report draws attention to antibody epitope prediction using computational tools, one of the crucial steps of vaccine design. Finally, regulatory issues, biosafety and public perception of this technology are also discussed.
dc.relation.ispartofBriefings in Functional Genomicsen
dc.subjectEpitope predictionen
dc.subjectComputational toolsen
dc.subjectGenetic engineeringen
dc.subjectEdible vaccineen
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleVaccine and antibody production in plants : developments and computational toolsen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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