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dc.contributor.authorHernandez-Santiago, Virginia
dc.contributor.authorDavey, Peter G.
dc.contributor.authorNathwani, Dilip
dc.contributor.authorMarwick, Charis A.
dc.contributor.authorGuthrie, Bruce
dc.date.accessioned2019-06-18T09:30:08Z
dc.date.available2019-06-18T09:30:08Z
dc.date.issued2019-06-07
dc.identifier.citationHernandez-Santiago , V , Davey , P G , Nathwani , D , Marwick , C A & Guthrie , B 2019 , ' Changes in resistance among coliform bacteraemia associated with a primary care antimicrobial stewardship intervention : a population-based interrupted time series study ' , PLoS Medicine , vol. 16 , no. 6 , e1002825 . https://doi.org/10.1371/journal.pmed.1002825en
dc.identifier.issn1549-1277
dc.identifier.otherPURE: 259345273
dc.identifier.otherPURE UUID: 08a90eae-346a-487a-b4e4-4e84e05c0966
dc.identifier.otherRIS: urn:AA2581D92A47682E696ECD1DF1566194
dc.identifier.otherScopus: 85067536871
dc.identifier.otherWOS: 000473778000010
dc.identifier.urihttp://hdl.handle.net/10023/17915
dc.descriptionVHS was supported by a Scottish Government Chief Scientist Office (https://www.cso.scot.nhs.uk/) Clinical Academic Training Fellowship (Grant reference number: CAF/12/07) for the duration of this work.en
dc.description.abstractBackground:  Primary care antimicrobial stewardship interventions can improve antimicrobial prescribing, but there is less evidence that they reduce rates of resistant infection. This study examined changes in broad-spectrum antimicrobial prescribing in the community and resistance in people admitted to hospital with community-associated coliform bacteraemia associated with a primary care stewardship intervention. Methods and findings:  Segmented regression analysis of data on all patients registered with a general practitioner in the National Health Service (NHS) Tayside region in the east of Scotland, UK, from 1 January 2005 to 31 December 2015 was performed, examining associations between a primary care antimicrobial stewardship intervention in 2009 and primary care prescribing of fluoroquinolones, cephalosporins, and co-amoxiclav and resistance to the same three antimicrobials/classes among community-associated coliform bacteraemia. Prescribing outcomes were the rate per 1,000 population prescribed each antimicrobial/class per quarter. Resistance outcomes were proportion of community-associated (first 2 days of hospital admission) coliform (Escherichia coli, Proteus spp., or Klebsiella spp.) bacteraemia among adult (18+ years) patients resistant to each antimicrobial/class. 11.4% of 3,442,205 oral antimicrobial prescriptions dispensed in primary care over the study period were for targeted antimicrobials. There were large, statistically significant reductions in prescribing at 1 year postintervention that were larger by 3 years postintervention when the relative reduction was −68.8% (95% CI −76.3 to −62.1) and the absolute reduction −6.3 (−7.6 to −5.2) people exposed per 1,000 population per quarter for fluoroquinolones; relative −74.0% (−80.3 to −67.9) and absolute reduction −6.1 (−7.2 to −5.2) for cephalosporins; and relative −62.3% (−66.9 to −58.1) and absolute reduction −6.8 (−7.7 to −6.0) for co-amoxiclav, all compared to their prior trends. There were 2,143 eligible bacteraemia episodes involving 2,004 patients over the study period (mean age 73.7 [SD 14.8] years; 51.4% women). There was no increase in community-associated coliform bacteraemia admissions associated with reduced community broad-spectrum antimicrobial use. Resistance to targeted antimicrobials reduced by 3.5 years postintervention compared to prior trends, but this was not statistically significant for co-amoxiclav. Relative and absolute changes were −34.7% (95% CI −52.3 to −10.6) and −63.5 (−131.8 to −12.8) resistant bacteraemia per 1,000 bacteraemia per quarter for fluoroquinolones; −48.3% (−62.7 to −32.3) and −153.1 (−255.7 to −77.0) for cephalosporins; and −17.8% (−47.1 to 20.8) and −63.6 (−206.4 to 42.4) for co-amoxiclav, respectively. Overall, there was reversal of a previously rising rate of fluoroquinolone resistance and flattening of previously rising rates of cephalosporin and co-amoxiclav resistance. The limitations of this study include that associations are not definitive evidence of causation and that potential effects of underlying secular trends in the postintervention period and/or of other interventions occurring simultaneously cannot be definitively excluded. Conclusions:  In this population-based study in Scotland, compared to prior trends, there were very large reductions in community broad-spectrum antimicrobial use associated with the stewardship intervention. In contrast, changes in resistance among coliform bacteraemia were more modest. Prevention of resistance through judicious use of new antimicrobials may be more effective than trying to reverse resistance that has become established.
dc.format.extent19
dc.language.isoeng
dc.relation.ispartofPLoS Medicineen
dc.rightsCopyright: © 2019 Hernandez-Santiago et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectE-DASen
dc.subject.lccRA0421en
dc.titleChanges in resistance among coliform bacteraemia associated with a primary care antimicrobial stewardship intervention : a population-based interrupted time series studyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1371/journal.pmed.1002825
dc.description.statusPeer revieweden


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