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dc.contributor.authorO’Mahoney, Paul
dc.contributor.authorHaigh, Neil
dc.contributor.authorWood, Kenny
dc.contributor.authorBrown, C. Tom A.
dc.contributor.authorIbbotson, Sally
dc.contributor.authorEadie, Ewan
dc.date.accessioned2019-06-17T23:40:56Z
dc.date.available2019-06-17T23:40:56Z
dc.date.issued2018-09
dc.identifier.citationO’Mahoney , P , Haigh , N , Wood , K , Brown , C T A , Ibbotson , S & Eadie , E 2018 , ' A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy ' , Photodiagnosis and Photodynamic Therapy , vol. 23 , pp. 144-150 . https://doi.org/10.1016/j.pdpdt.2018.06.013en
dc.identifier.issn1572-1000
dc.identifier.otherPURE: 253394514
dc.identifier.otherPURE UUID: aa43eb19-5f64-4907-972f-edda95cc3a9b
dc.identifier.otherRIS: urn:F345DC15CF118633D1BC3870D3FE787E
dc.identifier.otherScopus: 85049317841
dc.identifier.otherWOS: 000446285400027
dc.identifier.urihttp://hdl.handle.net/10023/17909
dc.descriptionThis project was supported by the University of St. Andrews through the Science and Technology Facilities Council (STFC) Impact Accelerator Award (IAA) and by the Laser Research and Therapy Fund (registered charity SC030850). P O’M is funded by Medi-lase (registered charity SC 037390) and the Alfred Stewart Trust.en
dc.description.abstractObjectives: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge. Methods: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match. The uniformity of the light source is characterised on a flat surface, a model head and a model leg. For context, a typical conventional PDT light source is also characterised. Additionally, the wavelength uniformity across the treatment site is characterised. Results: The PpIX-weighted spectrum of the novel light source matches with PpIX-weighted daylight spectrum, with irradiance values within the bounds for effective dPDT. By tuning the direction of light emission, improvements are seen in the uniformity across large anatomical surfaces. Wavelength uniformity is discussed. Conclusions: We have developed a light source that addresses the challenges in uniform, multiwavelength light distribution for large area artificial dPDT across curved anatomical surfaces.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapyen
dc.rights© 2018 Elsevier Ltd. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.pdpdt.2018.06.013en
dc.subjectPhotodynamic therapyen
dc.subjectPDTen
dc.subjectUniformityen
dc.subjectLight sourceen
dc.subjectActinic keratosisen
dc.subjectQC Physicsen
dc.subjectRL Dermatologyen
dc.subjectNDASen
dc.subject.lccQCen
dc.subject.lccRLen
dc.titleA novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapyen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1016/j.pdpdt.2018.06.013
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-06-18


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