The crystal structure of (RS)-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one : two hydrogen bonds generate an elegant three-dimensional framework structure
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In the title compound, C61H15ClN2O3, the heterocyclic ring adopts an envelope conformation, folded across the N⋯N line, with the 2,5-dimethoxyphenyl unit occupying a quasi-axial site. There are two N—H⋯O hydrogen bonds in the structure: one hydrogen bond links molecules related by a 41 screw axis to form a C(6) chain, and the other links inversion-related pairs of molecules to form an R22(8) ring. The ring motif links all of the chains into a continuous three-dimensional framework structure. Comparisons are made with the structures of some related compounds.
Narasimhamurthy , K H , . , C , Sagar , B K , Rangappa , K S , Yathirajan , H S & Glidewell , C 2019 , ' The crystal structure of ( RS )-7-chloro-2-(2,5-dimethoxyphenyl)-2,3-dihydroquinazolin-4(1 H )-one : two hydrogen bonds generate an elegant three-dimensional framework structure ' , Acta Crystallographica Section E , vol. 75 , no. 6 , pp. 843-847 . https://doi.org/10.1107/S2056989019007023
Acta Crystallographica Section E
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DescriptionKHN is grateful to UGC, RFSMS, Government of India for a Research Fellowship. BKS thanks the University of Mysore, for research facilities.
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