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dc.contributor.authorBaldacchino, A.
dc.contributor.authorTolomeo, S.
dc.contributor.authorBalfour, David
dc.contributor.authorMatthews, Keith
dc.date.accessioned2019-05-19T23:37:50Z
dc.date.available2019-05-19T23:37:50Z
dc.date.issued2019-05
dc.identifier.citationBaldacchino , A , Tolomeo , S , Balfour , D & Matthews , K 2019 , ' Profiles of visuospatial memory dysfunction in opioid exposed and dependent populations ' , Psychological Medicine , vol. 49 , no. 7 , pp. 1174-1184 . https://doi.org/10.1017/S0033291718003318en
dc.identifier.issn0033-2917
dc.identifier.otherPURE: 256162773
dc.identifier.otherPURE UUID: 32674021-8706-4a81-b9fd-633111d9e288
dc.identifier.otherScopus: 85056830633
dc.identifier.otherORCID: /0000-0002-5388-7376/work/60196783
dc.identifier.otherWOS: 000474921600012
dc.identifier.urihttp://hdl.handle.net/10023/17729
dc.description.abstractBackground . Chronic opioid exposure is common world-wide, but behavioural performance remains under-investigated. This study aimed to investigate visuospatial memory performance in opioid-exposed and dependent clinical populations and its associations with measures of intelligence and cognitive impulsivity. Methods . We recruited 109 participants: (i) patients with a history of opioid dependence due to chronic heroin use (n = 24), (ii) heroin users stabilised on methadone maintenance treatment (n = 29), (iii) participants with a history of chronic pain and prescribed tramadol and codeine (n = 28) and (iv) healthy controls (n = 28). The neuropsychological tasks from the Cambridge Neuropsychological Test Automated Battery included the Delayed Matching to Sample (DMS), Pattern Recognition Memory, Spatial Recognition Memory, Paired Associate Learning, Spatial Span Task, Spatial Working Memory and Cambridge Gambling Task. Pre-morbid general intelligence was assessed using the National Adult Reading Test. Results . As hypothesised, this study identified the differential effects of chronic heroin and methadone exposures on neuropsychological measures of visuospatial memory (p < 0.01) that were independent of injecting behaviour and dependence status. The study also identified an improvement in DMS performance (specifically at longer delays) when the methadone group was compared with the heroin group and also when the heroin group was stabilised onto methadone. Results identified differential effects of chronic heroin and methadone exposures on various neuropsychological measures of visuospatial memory independently from addiction severity measures, such as injecting behaviour and dependence status.
dc.format.extent27
dc.language.isoeng
dc.relation.ispartofPsychological Medicineen
dc.rights© 2018, Cambridge University Press. This work has been made available online in accordance with the publisher's policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1017/S0033291718003318en
dc.subjectCodeineen
dc.subjectCognitionen
dc.subjectHeroinen
dc.subjectMethadoneen
dc.subjectOpiodsen
dc.subjectTramadolen
dc.subjectVisuospatial memoryen
dc.subjectBF Psychologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccBFen
dc.subject.lccRC0321en
dc.titleProfiles of visuospatial memory dysfunction in opioid exposed and dependent populationsen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews.Centre for Minorities Research (CMR)en
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1017/S0033291718003318
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-05-20


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