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dc.contributor.authorLynn, Debra Alana
dc.contributor.authorBrown, Gillian Ruth
dc.identifier.citationLynn , D A & Brown , G R 2010 , ' The ontogeny of anxiety-like behavior in rats from adolescence to adulthood ' , Developmental Psychobiology , vol. 52 , no. 8 , pp. 731-739 .
dc.identifier.otherPURE: 467106
dc.identifier.otherPURE UUID: d86be96f-855f-428a-937c-a9b893e793bc
dc.identifier.otherstandrews_research_output: 31963
dc.identifier.otherScopus: 78649715882
dc.identifier.otherORCID: /0000-0002-0675-0780/work/60195733
dc.descriptionFunding provided for Gillian Brown by Wellcome Trust grant 078405/Z/05/Zen
dc.description.abstractIn human beings, susceptibility to anxiety disorders can be relatively high during adolescence. Understanding the ontogeny of anxiety-like behavior in laboratory rodents has implications for developing anxiolytic drugs that are suitable for this age group. Given the dearth of information about adolescent rodents, this study examined the response of both male and female adolescent, late adolescent, young adult, and older adult rats to three tests of anxiety-like behavior: the emergence test (ET), open field (OF), and elevated plus-maze (EPM). The results showed that adolescent rats exhibited a higher anxiety-like response than adults on each test; the amount of locomotion in the OF and percentage of time spent on the open arms of the EPM increased across the age groups, while older adult rats made the fewest start box re-entries in the ET. These results support the hypothesis that adolescent rats have a more pronounced response to stressors than do adults. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 731–739, 2010.
dc.relation.ispartofDevelopmental Psychobiologyen
dc.rights(c)2010 Wiley Periodicals Inc. OnlineOpen article deposited by permission of the publisher may be used for non-commercial purposes.en
dc.subjectOpen fielden
dc.subjectElevated plus-mazeen
dc.subjectSex differencesen
dc.subjectQL Zoologyen
dc.titleThe ontogeny of anxiety-like behavior in rats from adolescence to adulthooden
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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