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Factors associated with recruitment to randomised controlled trials in general practice : protocol for a systematic review

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Moffat_2019_Trials_Recruitment_CC.pdf (337.8Kb)
Date
10/05/2019
Author
Moffat, Keith Ra.
Cannon, Paul
Shi, Wen
Sullivan, Frank
Keywords
Recruitment
General practice
Randomised controlled trial
HD28 Management. Industrial Management
RA Public aspects of medicine
T-NDAS
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Abstract
Background: Randomised controlled trials (RCTs) are frequently unable to recruit sufficient numbers of participants. This affects the trial’s ability to answer the proposed research question, wastes resources and can be unethical. RCTs within a general practice setting are increasingly common and similarly face recruitment challenges. The aim of the proposed review is to identify factors that are associated with recruitment rates to RCTs in a general practice setting. These results will be used in further research to predict recruitment to RCTs. Methods/design: The electronic databases Medline, EMBASE, Cochrane Database of Systematic Reviews, NTIS and OpenGrey will be searched for relevant articles with no limit on the date of publication. BMC Trials will be manually searched for the past 5 years. Both quantitative and qualitative studies will be included if they have studied recruitment within a general practice RCT. Only English language publications will be included. Screening, quality assessment and data extraction will be conducted by two review authors not blinded to study characteristics. Disagreement will be resolved by discussion and the involvement of a third review author if required. A narrative synthesis of the studies included will be performed. Discussion: The review will, for the first time, systematically synthesise existing research on factors associated with recruitment rates to RCTs in general practice. By identifying research gaps to be prioritised in further research, it will be of interest to academics. It will also be of value to clinical trialists who are involved in the complex task of improving trial recruitment. Our team will use the findings to inform a prediction model of trial recruitment using machine learning.
Citation
Moffat , K R , Cannon , P , Shi , W & Sullivan , F 2019 , ' Factors associated with recruitment to randomised controlled trials in general practice : protocol for a systematic review ' , Trials , vol. 20 , 66 . https://doi.org/10.1186/s13063-019-3354-z
Publication
Trials
Status
Peer reviewed
DOI
https://doi.org/10.1186/s13063-019-3354-z
ISSN
1745-6215
Type
Journal article
Rights
Copyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Description
This study is supported by a PhD studentship provided by the University of St Andrews.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/17697

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