Electron carriers and energy conservation in mitochondrial respiration
MetadataShow full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
The chemical system for the transformation of energy in eukaryotic mitochondria has engaged researchers for almost a century. This summary of four lectures on the electron transport system in mitochondria is an introduction to the mammalian electron transport chain for those unfamiliar with mitochondrial oxidative phosphorylation. It gives references chosen to reflect the history of the field and to highlight some of the recent advances in bioenergetics. The electron transport chain converts the energy that is released as electrons are passed to carriers of progressively higher redox potential into a proton gradient across the membrane that drives adenosine triphosphate (ATP) synthesis. The electron carriers include flavins, iron–sulfur centers, heme groups, and copper to divide the redox change from reduced nicotinamide adenine dinucleotide (NADH) at −320 mV to oxygen at +800 mV into steps that allow conversion and conservation of the energy released in three major complexes (Complexes I, III, and IV) by moving protons across the mitochondrial inner membrane. The three processes of proton pumping are now known after the successful determination of the structures of the large membrane protein complexes involved. Mitochondria and their proteins play roles not only in the production of ATP but also in cell survival, for which energy supply is the key.
Ramsay , R R 2019 , ' Electron carriers and energy conservation in mitochondrial respiration ' , ChemTexts , vol. 5 , 9 . https://doi.org/10.1007/s40828-019-0085-4
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.