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dc.contributor.authorSanderson, Rowan W.
dc.contributor.authorCuratolo, Andrea
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorChin, Lixin
dc.contributor.authorKennedy, Brendan F.
dc.date.accessioned2019-04-11T15:30:01Z
dc.date.available2019-04-11T15:30:01Z
dc.date.issued2019-04-01
dc.identifier258564406
dc.identifiereac388f1-4e37-4d79-a589-8d53d6be83f3
dc.identifier000462887400018
dc.identifier85064442205
dc.identifier000462887400018
dc.identifier.citationSanderson , R W , Curatolo , A , Wijesinghe , P , Chin , L & Kennedy , B F 2019 , ' Finger-mounted quantitative micro-elastography ' , Biomedical Optics Express , vol. 10 , no. 4 , pp. 1760-1773 . https://doi.org/10.1364/BOE.10.001760en
dc.identifier.issn2156-7085
dc.identifier.otherORCID: /0000-0002-8378-7261/work/56424287
dc.identifier.urihttps://hdl.handle.net/10023/17504
dc.descriptionFunding: Australian Research Council (ARC); the Cancer Council, Western Australia; OncoRes Medical; War Widows' Guild of Western Australia Scholarship.en
dc.description.abstractWe present a finger-mounted quantitative micro-elastography (QME) probe, capable of measuring the elasticity of biological tissue in a format that avails of the dexterity of the human finger. Finger-mounted QME represents the first demonstration of a wearable elastography probe. The approach realizes optical coherence tomography-based elastography by focusing the optical beam into the sample via a single-mode fiber that is fused to a length of graded-index fiber. The fiber is rigidly affixed to a 3D-printed thimble that is mounted on the finger. Analogous to manual palpation, the probe compresses the tissue through the force exerted by the finger. The resulting deformation is measured using optical coherence tomography. Elasticity is estimated as the ratio of local stress at the sample surface, measured using a compliant layer, to the local strain in the sample. We describe the probe fabrication method and the signal processing developed to achieve accurate elasticity measurements in the presence of motion artifact. We demonstrate the probe's performance in motion-mode scans performed on homogeneous, bi-layer and inclusion phantoms and its ability to measure a thermally-induced increase in elasticity in ex vivo muscle tissue. In addition, we demonstrate the ability to acquire 2D images with the finger-mounted probe where lateral scanning is achieved by swiping the probe across the sample surface
dc.format.extent14
dc.format.extent6955625
dc.language.isoeng
dc.relation.ispartofBiomedical Optics Expressen
dc.subjectQC Physicsen
dc.subjectR Medicine (General)en
dc.subjectT Technology (General)en
dc.subjectNDASen
dc.subject.lccQCen
dc.subject.lccR1en
dc.subject.lccT1en
dc.titleFinger-mounted quantitative micro-elastographyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doi10.1364/BOE.10.001760
dc.description.statusPeer revieweden


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