Show simple item record

Files in this item


Item metadata

dc.contributor.authorLi, Wen-Chang
dc.contributor.authorSoffe, Stephen
dc.identifier.citationLi , W-C & Soffe , S 2019 , ' Stimulation of single, possible CHX10 hindbrain neurons turns swimming on and off in young Xenopus tadpoles ' , Frontiers in Cellular Neuroscience , vol. 13 , 47 .
dc.identifier.otherPURE: 257592956
dc.identifier.otherPURE UUID: c90139f5-9640-47b0-bff5-5f2d9e7fece8
dc.identifier.otherScopus: 85064211483
dc.identifier.otherWOS: 000459089300001
dc.identifier.otherORCID: /0000-0002-1179-6636/work/64361122
dc.descriptionAuthors thank Royal Society, Wellcome Trust and BBSRC (BB/L00111X) for their support in the past.en
dc.description.abstractVertebrate central pattern generators (CPGs) controlling locomotion contain neurons which provide the excitation that drives and maintains network rhythms. In a simple vertebrate, the developing Xenopus tadpole, we study the role of excitatory descending neurons with ipsilateral projecting axons (descending interneurons, dINs) in the control of swimming rhythms. In tadpoles with both intact central nervous system (CNS) and transections in the hindbrain, exciting some individual dINs in the caudal hindbrain region could start swimming repeatedly. Analyses indicated the recruitment of additional dINs immediately after such evoked dIN spiking and prior to swimming. Excitation of dINs can therefore be sufficient for the initiation of swimming. These “powerful” dINs all possessed both ascending and descending axons. However, their axon projection lengths were not different from those of other excitatory dINs at similar locations. The dorsoventral position of dINs, as a population, significantly better matched that of cells marked by immunocytochemistry for the transcription factor CHX10 than other known neuron types in the ventral hindbrain and spinal cord. The comparison suggests that the excitatory interneurons including dINs are CHX10-positive, in agreement with CHX10 as a marker for excitatory neurons with ipsilateral projections in the spinal cord and brainstem of other vertebrates. Overall, our results further demonstrate the key importance of dINs in driving tadpole swimming rhythms.
dc.relation.ispartofFrontiers in Cellular Neuroscienceen
dc.rightsCopyright © 2019 Li and Soffe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectCentral pattern generatoren
dc.subjectExcitatory interneuronsen
dc.subjectSpinal corden
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleStimulation of single, possible CHX10 hindbrain neurons turns swimming on and off in young Xenopus tadpolesen
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record