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Phospholipases A1

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SmithIntJMolSci2011Phospholipases.pdf (421.4Kb)
Date
01/2011
Author
Richmond, Gregory S.
Smith, Terry K.
Keywords
Phospholipase A(1)
Phospholipid
Lysophospholipid
Mammalian sec23p-interacting protein
Platelet-activating-factor
Pig heart microsomes
Lipase gene family
Phosphatidic-acid
Arachidonic-acid
Trypanosoma-brucei
Escherichia-coli
Bovine brain
Guinea-pig
QH426 Genetics
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Abstract
Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.
Citation
Richmond , G S & Smith , T K 2011 , ' Phospholipases A 1 ' , International Journal of Molecular Sciences , vol. 12 , no. 1 , pp. 588-612 . https://doi.org/10.3390/ijms12010588
Publication
International Journal of Molecular Sciences
Status
Peer reviewed
DOI
https://doi.org/10.3390/ijms12010588
ISSN
1422-0067
Type
Journal item
Rights
© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Description
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/1708

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