Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications
Abstract
It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.
Citation
Gregg , S T , Yuan , Q , Morris , R E & Xiao , B 2017 , ' Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications ' , Materials Today Communications , vol. 12 , pp. 95-105 . https://doi.org/10.1016/j.mtcomm.2017.07.007
Publication
Materials Today Communications
Status
Peer reviewed
ISSN
2352-4928Type
Journal article
Rights
© 2017 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.mtcomm.2017.07.007
Description
The authors gratefully appreciate the supports from EPSRC (EP/M027295/1), the initial research funding from Queen’s University Belfast and Aston University, and the DEL PhD studentship.Collections
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