Assessing host-virus codivergence for close relatives of Merkel cell polyomavirus infecting African great apes
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It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV. We reassess this question by focusing on a single lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage. By characterizing the genetic diversity of these viruses in seven African great ape taxa, we show that they exhibit very strong host specificity. Reconciliation analyses identify more codivergence than noncodivergence events. In addition, we find that a number of host and PyV divergence events are synchronous. Collectively, our results support codivergence as the dominant process at play during the evolution of the MCPyV lineage. More generally, our results add to the growing body of evidence suggesting an ancient and stable association of PyV and their animal hosts.
Madinda , N F , Ehlers , B , Wertheim , J O , Akoua-Koffi , C , Bergl , R A , Boesch , C , Akonkwa , D B M , Eckardt , W , Fruth , B , Gillespie , T R , Gray , M , Hohmann , G , Karhemere , S , Kujirakwinja , D , Langergraber , K , Muyembe , J J , Nishuli , R , Pauly , M , Petrzelkova , K J , Robbins , M M , Todd , A , Schubert , G , Stoinski , T S , Wittig , R M , Zuberbühler , K , Peeters , M , Leendertz , F H & Calvignac-Spencer , S 2016 , ' Assessing host-virus codivergence for close relatives of Merkel cell polyomavirus infecting African great apes ' Journal of Virology , vol. 90 , no. 19 , pp. 8531-8541 . https://doi.org/10.1128/JVI.00247-16
Journal of Virology
Copyright © 2016, American Society for Microbiology. All Rights Reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1128/JVI.00247-16
DescriptionThis work, including the efforts of Klara Judita Petrzelkova, was funded by Academy of Sciences of the Czech Republic (RVO68081766). This work, including the efforts of Klara Judita Petrzelkova, was funded by Grant Agency of the Czech Republic (206/09/0927). This work, including the efforts of Joel O. Wertheim, was funded by University of California Laboratory Fees Research Program (12-LR-236617). This work, including the efforts of Joel O. Wertheim, was funded by HHS | National Institutes of Health (NIH) (K01-AI110181). This work, including the efforts of Martine Peeters, was funded by Agence Nationale de Recherches sur le Sida et les Hepatites Virales (ANRS) (12125, 12182, 12555, and 12325).
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