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dc.contributor.authorSobczak, Amelie Isabelle Sylvie
dc.contributor.authorStefanowicz, Fiona
dc.contributor.authorPitt, Samantha Jane
dc.contributor.authorAjjan, Ramzi A.
dc.contributor.authorStewart, Alan James
dc.date.accessioned2019-01-24T12:30:05Z
dc.date.available2019-01-24T12:30:05Z
dc.date.issued2019-02
dc.identifier.citationSobczak , A I S , Stefanowicz , F , Pitt , S J , Ajjan , R A & Stewart , A J 2019 , ' Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes ' BioMetals , vol. 32 , no. 1 , pp. 123-138 . https://doi.org/10.1007/s10534-018-00167-zen
dc.identifier.issn0966-0844
dc.identifier.otherPURE: 257066696
dc.identifier.otherPURE UUID: 4af1f1ff-ff43-4245-8de9-699a1c5c9900
dc.identifier.otherScopus: 85060550173
dc.identifier.otherORCID: /0000-0003-4580-1840/work/60195798
dc.identifier.otherORCID: /0000-0003-2257-1595/work/60196228
dc.identifier.otherWOS: 000457691700011
dc.identifier.urihttp://hdl.handle.net/10023/16930
dc.descriptionThis work was supported by the British Heart Foundation (grant codes: PG/15/9/31270 and FS/15/42/31556).en
dc.description.abstractGlycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. This effect was observed in females but not males. In T2DM, the highest quartile of selenium concentrations and the third quartile of copper concentrations associated with the absence of diabetes in males. The highest quartile of magnesium concentrations was associated with the absence of T2DM in males but not females. HbA1c correlated with plasma concentrations of magnesium (negatively, in both sexes together in T1DM and T1DM males), copper (positively, in T1DM males and in both sexes together in T2DM), selenium (positively, in both sexes together in T1DM and T2DM, and T2DM females) and with zinc/copper ratio (negatively, in both sexes together in T1DM and T2DM). This study shows that plasma magnesium concentration is altered to the highest degree in T1DM, while in T2DM, plasma selenium and copper concentrations are significantly affected. This work increases our understanding of how T1DM and T2DM affects plasma metal concentrations and may have future implications for diabetes management.
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofBioMetalsen
dc.rights© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectDiabetesen
dc.subjectHbA1cen
dc.subjectICP-MSen
dc.subjectMetal homeostasisen
dc.subjectZinc/copper ratioen
dc.subjectQH301 Biologyen
dc.subjectRC Internal medicineen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccRCen
dc.titleTotal plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.identifier.doihttps://doi.org/10.1007/s10534-018-00167-z
dc.description.statusPeer revieweden


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