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Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes
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dc.contributor.author | Sobczak, Amelie Isabelle Sylvie | |
dc.contributor.author | Stefanowicz, Fiona | |
dc.contributor.author | Pitt, Samantha Jane | |
dc.contributor.author | Ajjan, Ramzi A. | |
dc.contributor.author | Stewart, Alan James | |
dc.date.accessioned | 2019-01-24T12:30:05Z | |
dc.date.available | 2019-01-24T12:30:05Z | |
dc.date.issued | 2019-02 | |
dc.identifier | 257066696 | |
dc.identifier | 4af1f1ff-ff43-4245-8de9-699a1c5c9900 | |
dc.identifier | 85060550173 | |
dc.identifier | 000457691700011 | |
dc.identifier.citation | Sobczak , A I S , Stefanowicz , F , Pitt , S J , Ajjan , R A & Stewart , A J 2019 , ' Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes ' , BioMetals , vol. 32 , no. 1 , pp. 123-138 . https://doi.org/10.1007/s10534-018-00167-z | en |
dc.identifier.issn | 0966-0844 | |
dc.identifier.other | ORCID: /0000-0003-4580-1840/work/60195798 | |
dc.identifier.other | ORCID: /0000-0003-2257-1595/work/60196228 | |
dc.identifier.uri | https://hdl.handle.net/10023/16930 | |
dc.description | This work was supported by the British Heart Foundation (grant codes: PG/15/9/31270 and FS/15/42/31556). | en |
dc.description.abstract | Glycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. This effect was observed in females but not males. In T2DM, the highest quartile of selenium concentrations and the third quartile of copper concentrations associated with the absence of diabetes in males. The highest quartile of magnesium concentrations was associated with the absence of T2DM in males but not females. HbA1c correlated with plasma concentrations of magnesium (negatively, in both sexes together in T1DM and T1DM males), copper (positively, in T1DM males and in both sexes together in T2DM), selenium (positively, in both sexes together in T1DM and T2DM, and T2DM females) and with zinc/copper ratio (negatively, in both sexes together in T1DM and T2DM). This study shows that plasma magnesium concentration is altered to the highest degree in T1DM, while in T2DM, plasma selenium and copper concentrations are significantly affected. This work increases our understanding of how T1DM and T2DM affects plasma metal concentrations and may have future implications for diabetes management. | |
dc.format.extent | 16 | |
dc.format.extent | 967108 | |
dc.language.iso | eng | |
dc.relation.ispartof | BioMetals | en |
dc.subject | Diabetes | en |
dc.subject | HbA1c | en |
dc.subject | ICP-MS | en |
dc.subject | Metal homeostasis | en |
dc.subject | Zinc/copper ratio | en |
dc.subject | QH301 Biology | en |
dc.subject | RC Internal medicine | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC | en |
dc.title | Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes | en |
dc.type | Journal article | en |
dc.contributor.sponsor | British Heart Foundation | en |
dc.contributor.sponsor | British Heart Foundation | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.identifier.doi | https://doi.org/10.1007/s10534-018-00167-z | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | FS/15/42/31556 | en |
dc.identifier.grantnumber | PG/15/9/31270 | en |
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