A high-throughput screening of a chemical compound library in ovarian cancer stem cells
MetadataShow full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Background: Epithelial ovarian cancer has a poor prognosis, mostly due to its late diagnosis and to the development of drug resistance after a first platinum-based regimen. The presence of a specific population of “cancer stem cells” could be responsible of the relapse of the tumor, and of the development of resistance to therapy. For this reason, it would be important to specifically target this subpopulation of tumor cells in order to increase the response to therapy. Method: We screened a chemical compound library assembled during the COST CM1106 action to search for compound classes active in targeting ovarian stem cells. We here report the results of the high-throughput screening assay in two ovarian cancer stem cells and the differentiated cells derived from them. Results and conclusion: Interestingly there were compounds active only on stem cells, only on differentiated cells and compounds active on both cell populations. Even if these data need to be validated in ad hoc dose response cytotoxic experiments, the ongoing analysis of the compound structures will open up to mechanistic drug studies to select compounds able to improve the prognosis of ovarian cancer patients.
Ricci , F , Carrassa , L , Christodoulou , M S , Passarella , D , Michel , B , Benhida , B , Martinet , N , Hunyadi , A , Ioannou , E , Roussis , V , Musso , L , Dallavalle , S , Silvestri , R , Westwood , N J , Mori , M , Ingallina , C , Botta , B , Kavetsou , E , Detsi , A , Majer , Z , Hudecz , F , Bősze , S , Kaminska , B , Hansen , T V , Bertrand , P , Athanassopoulos , C M & Damia , G 2018 , ' A high-throughput screening of a chemical compound library in ovarian cancer stem cells ' , Combinatorial Chemistry and High Throughput Screening , vol. 21 , no. 1 , pp. 50-56 . https://doi.org/10.2174/1386207321666180124093406
Combinatorial Chemistry and High Throughput Screening
© 2018 Bentham Science Publishers. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.2174/1386207321666180124093406
DescriptionThis work was performed under the frame of COST Action collaboration (COST Action CM1106). The generous contribution of AIRC (The Italian Association for Cancer Research) IG14536 to G.D. is gratefully acknowledged. A.H. acknowledges support from the János Bolyai fellowship of the Hungarian Academy of Sciences.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.