Files in this item
Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila
Item metadata
dc.contributor.author | Oswald, Matthew C W | |
dc.contributor.author | Brooks, Paul S. | |
dc.contributor.author | Zwart, Maarten F. | |
dc.contributor.author | Mukherjee, Amrita | |
dc.contributor.author | West, Ryan J H | |
dc.contributor.author | Giachello, Carlo N G | |
dc.contributor.author | Morarach, Khomgrit | |
dc.contributor.author | Baines, Richard A. | |
dc.contributor.author | Sweeney, Sean T. | |
dc.contributor.author | Landgraf, Matthias | |
dc.date.accessioned | 2019-01-11T16:30:05Z | |
dc.date.available | 2019-01-11T16:30:05Z | |
dc.date.issued | 2018-12-27 | |
dc.identifier | 257312507 | |
dc.identifier | f0b6c9fc-ff31-4376-a08f-000a47525e87 | |
dc.identifier | 85059240135 | |
dc.identifier | 30540251 | |
dc.identifier.citation | Oswald , M C W , Brooks , P S , Zwart , M F , Mukherjee , A , West , R J H , Giachello , C N G , Morarach , K , Baines , R A , Sweeney , S T & Landgraf , M 2018 , ' Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila ' , eLife , vol. 7 , e39393 . https://doi.org/10.7554/eLife.39393 | en |
dc.identifier.issn | 2050-084X | |
dc.identifier.other | ORCID: /0000-0002-5073-8631/work/52572487 | |
dc.identifier.uri | https://hdl.handle.net/10023/16845 | |
dc.description | This work was supported by BBSRC research grants (BB/IO1179X/1, BB/M002934/1) to ML, (BB/I012273/1, BB/M002322/1) to STS and (BB/N/014561/1) to RAB. | en |
dc.description.abstract | Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson's disease-linked protein DJ-1β as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction. | |
dc.format.extent | 27 | |
dc.format.extent | 1942281 | |
dc.language.iso | eng | |
dc.relation.ispartof | eLife | en |
dc.subject | D. melanogaster | en |
dc.subject | DJ-1 | en |
dc.subject | Drosophila | en |
dc.subject | Neuron | en |
dc.subject | Neuroscience | en |
dc.subject | Plasticity | en |
dc.subject | ROS (reactive oxygen species) | en |
dc.subject | Synapse | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | QH301 Biology | en |
dc.subject | Neuroscience(all) | en |
dc.subject | Biochemistry, Genetics and Molecular Biology(all) | en |
dc.subject | Immunology and Microbiology(all) | en |
dc.subject | DAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject.lcc | RC0321 | en |
dc.subject.lcc | QH301 | en |
dc.title | Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | 10.7554/eLife.39393 | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.