Insights into the catalytic activity of [Pd(NHC)(cin)Cl] (NHC = IPr, IPrCl, IPrBr) complexes in the Suzuki-Miyaura reaction
Abstract
The influence of C4,5-halogenation on palladium N-heterocyclic carbene complexes and their activity in the Suzuki-Miyaura reaction have been investigated. Two [Pd(NHC)(cin)Cl] complexes bearing IPrCl and IPrBr ligands were synthesized. After determining electronic and steric properties of these ligands, their properties were compared to those of [Pd(IPr)(cin)Cl]. The three palladium complexes were studied using DFT calculations to delineate their behaviour in the activation step leading to the putative 12-electron active catalyst. Experimentally, their catalytic activity in the Suzuki-Miyaura reaction involving a wide range of coupling partners (30 entries) at low catalyst loading was studied.
Citation
Izquierdo , F , Zinser , C , Minenkov , Y , Cordes , D , Slawin , A , Cavallo , L , Nahra , F , Cazin , C & Nolan , S P 2018 , ' Insights into the catalytic activity of [Pd(NHC)(cin)Cl] (NHC = IPr, IPr Cl , IPr Br ) complexes in the Suzuki-Miyaura reaction ' , ChemCatChem , vol. 10 , no. 3 , pp. 601-611 . https://doi.org/10.1002/cctc.201701279
Publication
ChemCatChem
Status
Peer reviewed
ISSN
1867-3899Type
Journal article
Description
The authors gratefully acknowledge the European Commission (EC) for funding through the seventh framework program SYNFLOW, the European Research Council (ERC) (Advanced Investigator Award “FUNCAT” to S. P. N.), The Engineering and Physical Sciences Research Council (EPSRC) and AstraZeneca (Studentship to C. M. Z.).Collections
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