Files in this item
Morphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solution
Item metadata
dc.contributor.author | Abazari, Reza | |
dc.contributor.author | reza Mahjoub, Ali | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.contributor.author | Carpenter-Warren, Cameron L. | |
dc.date.accessioned | 2018-12-16T00:37:43Z | |
dc.date.available | 2018-12-16T00:37:43Z | |
dc.date.issued | 2018-04 | |
dc.identifier | 251795953 | |
dc.identifier | c6af1e07-413a-4f2c-9aa9-2e951bab556a | |
dc.identifier | 85038859019 | |
dc.identifier | 000426021200064 | |
dc.identifier.citation | Abazari , R , reza Mahjoub , A , Slawin , A M Z & Carpenter-Warren , C L 2018 , ' Morphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solution ' , Ultrasonics Sonochemistry , vol. 42 , pp. 594-608 . https://doi.org/10.1016/j.ultsonch.2017.12.032 | en |
dc.identifier.issn | 1350-4177 | |
dc.identifier.other | RIS: urn:B46A84A5F48E5EE63DFEC23B1960D082 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/56861741 | |
dc.identifier.uri | https://hdl.handle.net/10023/16700 | |
dc.description | Support of this investigation by Tarbiat Modares University is gratefully acknowledged. | en |
dc.description.abstract | In this study, we have reported a biocompatible metal-organic framework (MOF) with ultra-high surface area, which we have shown to have uses as both a cancer treatment delivery system and for environmental applications. Using a sonochemical approach, highly flexible organic H3BTCTB and ditopic 4,4́′-BPDC ligands, along with modulators of acetic acid and pyridine were combined to prepare a Zn(II)-based metal-organic framework, DUT-32, [Zn4O(BPDC)(BTCTB)4/3(DEF)39.7(H2O)11.3]. Powder X-ray diffraction (PXRD), field-emission scanning electron microscopy (FE-SEM), and Fourier transform infrared spectroscopy (FTIR) were used to characterize, the particle size, shape, and structure of the DUT-32. To show the effects of shape and size of DUT-32 micro/nano-structures on doxorubicin (DOX) drug release and amoxicillin (AMX) adsorption, time of sonication, initial reagent concentrations, irradiation frequency, and acetic acid to pyridine molar ratios were optimized. The drug-loaded DUT-32 was soaked in simulated body fluid (SBF) and the drug release ratio was monitored through release time to perform in vitro drug release test. A slow and sustained release was observed for DUT-32 micro/nano-structures, having a considerable drug loading capacity. At the pH values 7.4-4.5, various profiles of pH-responsive release were achieved. Also, the prepared DUT-32 micro/nano-structures are found to be biocompatible with PC3 (prostate cancer) and HeLa (cervical cancer) cell lines, when tested by MTT assay. Moreover, DUT-32 micro/nano-structures were studied to show AMX adsorption from aqueous solution. Finally, kinetic studies indicated that AMX adsorption and drug release of DOX via this MOF are of first-order kinetics. | |
dc.format.extent | 5787861 | |
dc.language.iso | eng | |
dc.relation.ispartof | Ultrasonics Sonochemistry | en |
dc.subject | Metal-organic framework | en |
dc.subject | Modulator | en |
dc.subject | Drug delivery | en |
dc.subject | pH responsive release | en |
dc.subject | Doxorubicin | en |
dc.subject | Amoxicillin | en |
dc.subject | QD Chemistry | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QD | en |
dc.subject.lcc | RM | en |
dc.title | Morphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solution | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1016/j.ultsonch.2017.12.032 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-12-16 |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.