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dc.contributor.authorAbazari, Reza
dc.contributor.authorreza Mahjoub, Ali
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorCarpenter-Warren, Cameron L.
dc.date.accessioned2018-12-16T00:37:43Z
dc.date.available2018-12-16T00:37:43Z
dc.date.issued2018-04
dc.identifier251795953
dc.identifierc6af1e07-413a-4f2c-9aa9-2e951bab556a
dc.identifier85038859019
dc.identifier000426021200064
dc.identifier.citationAbazari , R , reza Mahjoub , A , Slawin , A M Z & Carpenter-Warren , C L 2018 , ' Morphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solution ' , Ultrasonics Sonochemistry , vol. 42 , pp. 594-608 . https://doi.org/10.1016/j.ultsonch.2017.12.032en
dc.identifier.issn1350-4177
dc.identifier.otherRIS: urn:B46A84A5F48E5EE63DFEC23B1960D082
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861741
dc.identifier.urihttps://hdl.handle.net/10023/16700
dc.descriptionSupport of this investigation by Tarbiat Modares University is gratefully acknowledged.en
dc.description.abstractIn this study, we have reported a biocompatible metal-organic framework (MOF) with ultra-high surface area, which we have shown to have uses as both a cancer treatment delivery system and for environmental applications. Using a sonochemical approach, highly flexible organic H3BTCTB and ditopic 4,4́′-BPDC ligands, along with modulators of acetic acid and pyridine were combined to prepare a Zn(II)-based metal-organic framework, DUT-32, [Zn4O(BPDC)(BTCTB)4/3(DEF)39.7(H2O)11.3]. Powder X-ray diffraction (PXRD), field-emission scanning electron microscopy (FE-SEM), and Fourier transform infrared spectroscopy (FTIR) were used to characterize, the particle size, shape, and structure of the DUT-32. To show the effects of shape and size of DUT-32 micro/nano-structures on doxorubicin (DOX) drug release and amoxicillin (AMX) adsorption, time of sonication, initial reagent concentrations, irradiation frequency, and acetic acid to pyridine molar ratios were optimized. The drug-loaded DUT-32 was soaked in simulated body fluid (SBF) and the drug release ratio was monitored through release time to perform in vitro drug release test. A slow and sustained release was observed for DUT-32 micro/nano-structures, having a considerable drug loading capacity. At the pH values 7.4-4.5, various profiles of pH-responsive release were achieved. Also, the prepared DUT-32 micro/nano-structures are found to be biocompatible with PC3 (prostate cancer) and HeLa (cervical cancer) cell lines, when tested by MTT assay. Moreover, DUT-32 micro/nano-structures were studied to show AMX adsorption from aqueous solution. Finally, kinetic studies indicated that AMX adsorption and drug release of DOX via this MOF are of first-order kinetics.
dc.format.extent5787861
dc.language.isoeng
dc.relation.ispartofUltrasonics Sonochemistryen
dc.subjectMetal-organic frameworken
dc.subjectModulatoren
dc.subjectDrug deliveryen
dc.subjectpH responsive releaseen
dc.subjectDoxorubicinen
dc.subjectAmoxicillinen
dc.subjectQD Chemistryen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQDen
dc.subject.lccRMen
dc.titleMorphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solutionen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.1016/j.ultsonch.2017.12.032
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-12-16


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