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dc.contributor.authorAbazari, Reza
dc.contributor.authorreza Mahjoub, Ali
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorCarpenter-Warren, Cameron L.
dc.date.accessioned2018-12-16T00:37:43Z
dc.date.available2018-12-16T00:37:43Z
dc.date.issued2018-04
dc.identifier.citationAbazari , R , reza Mahjoub , A , Slawin , A M Z & Carpenter-Warren , C L 2018 , ' Morphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solution ' , Ultrasonics Sonochemistry , vol. 42 , pp. 594-608 . https://doi.org/10.1016/j.ultsonch.2017.12.032en
dc.identifier.issn1350-4177
dc.identifier.otherPURE: 251795953
dc.identifier.otherPURE UUID: c6af1e07-413a-4f2c-9aa9-2e951bab556a
dc.identifier.otherRIS: urn:B46A84A5F48E5EE63DFEC23B1960D082
dc.identifier.otherScopus: 85038859019
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861741
dc.identifier.otherWOS: 000426021200064
dc.identifier.urihttps://hdl.handle.net/10023/16700
dc.descriptionSupport of this investigation by Tarbiat Modares University is gratefully acknowledged.en
dc.description.abstractIn this study, we have reported a biocompatible metal-organic framework (MOF) with ultra-high surface area, which we have shown to have uses as both a cancer treatment delivery system and for environmental applications. Using a sonochemical approach, highly flexible organic H3BTCTB and ditopic 4,4́′-BPDC ligands, along with modulators of acetic acid and pyridine were combined to prepare a Zn(II)-based metal-organic framework, DUT-32, [Zn4O(BPDC)(BTCTB)4/3(DEF)39.7(H2O)11.3]. Powder X-ray diffraction (PXRD), field-emission scanning electron microscopy (FE-SEM), and Fourier transform infrared spectroscopy (FTIR) were used to characterize, the particle size, shape, and structure of the DUT-32. To show the effects of shape and size of DUT-32 micro/nano-structures on doxorubicin (DOX) drug release and amoxicillin (AMX) adsorption, time of sonication, initial reagent concentrations, irradiation frequency, and acetic acid to pyridine molar ratios were optimized. The drug-loaded DUT-32 was soaked in simulated body fluid (SBF) and the drug release ratio was monitored through release time to perform in vitro drug release test. A slow and sustained release was observed for DUT-32 micro/nano-structures, having a considerable drug loading capacity. At the pH values 7.4-4.5, various profiles of pH-responsive release were achieved. Also, the prepared DUT-32 micro/nano-structures are found to be biocompatible with PC3 (prostate cancer) and HeLa (cervical cancer) cell lines, when tested by MTT assay. Moreover, DUT-32 micro/nano-structures were studied to show AMX adsorption from aqueous solution. Finally, kinetic studies indicated that AMX adsorption and drug release of DOX via this MOF are of first-order kinetics.
dc.language.isoeng
dc.relation.ispartofUltrasonics Sonochemistryen
dc.rights© 2017 Elsevier Ltd. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.ultsonch.2017.12.032en
dc.subjectMetal-organic frameworken
dc.subjectModulatoren
dc.subjectDrug deliveryen
dc.subjectpH responsive releaseen
dc.subjectDoxorubicinen
dc.subjectAmoxicillinen
dc.subjectQD Chemistryen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQDen
dc.subject.lccRMen
dc.titleMorphology- and size-controlled synthesis of a metal-organic framework under ultrasound irradiation : an efficient carrier for pH responsive release of anti-cancer drugs and their applicability for adsorption of amoxicillin from aqueous solutionen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1016/j.ultsonch.2017.12.032
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-12-16


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