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dc.contributor.authorHarkness, Gavin J.
dc.contributor.authorClarke, Matthew L.
dc.date.accessioned2018-12-01T00:50:33Z
dc.date.available2018-12-01T00:50:33Z
dc.date.issued2018-01-07
dc.identifier251694374
dc.identifier82e3c7f4-e10c-4e8f-a739-df1e74fb3612
dc.identifier85040160788
dc.identifier000419051200026
dc.identifier.citationHarkness , G J & Clarke , M L 2018 , ' Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers ' , Catalysis Science & Technology , vol. 8 , no. 1 , pp. 328-334 . https://doi.org/10.1039/C7CY01205Een
dc.identifier.issn2044-4753
dc.identifier.otherBibtex: urn:9515631e93afa20f5983e30ac40d5c86
dc.identifier.otherORCID: /0000-0002-2444-1244/work/59464599
dc.identifier.urihttps://hdl.handle.net/10023/16601
dc.descriptionThe authors thanks the EPSRC for funding in the initial stages of this work from EP/J018139/1 and from the DTG.en
dc.description.abstractThe challenging reaction of unactivated ortho-substituted aromatic ethers with Grignard reagents has been found to be most effectively catalysed using nickel complexes of less sterically hindered ligands. Air stable, cheap, commercially available [NiCl2(PnBu3)2] stands out as an improved catalyst for this type of transformation. The improved results with this catalyst even extend to some couplings of a more activated substrate when examined at higher temperatures and at catalyst loadings down to 0.1 mol%. Unusual induction periods in these latter reactions have been related to the by-product magnesium salts acting as co-catalysts.
dc.format.extent1241310
dc.language.isoeng
dc.relation.ispartofCatalysis Science & Technologyen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleLess hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethersen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.1039/C7CY01205E
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-12-01
dc.identifier.grantnumberEP/J018139/1en
dc.identifier.grantnumberEP/J018139/1en


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