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Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers
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dc.contributor.author | Harkness, Gavin J. | |
dc.contributor.author | Clarke, Matthew L. | |
dc.date.accessioned | 2018-12-01T00:50:33Z | |
dc.date.available | 2018-12-01T00:50:33Z | |
dc.date.issued | 2018-01-07 | |
dc.identifier | 251694374 | |
dc.identifier | 82e3c7f4-e10c-4e8f-a739-df1e74fb3612 | |
dc.identifier | 85040160788 | |
dc.identifier | 000419051200026 | |
dc.identifier.citation | Harkness , G J & Clarke , M L 2018 , ' Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers ' , Catalysis Science & Technology , vol. 8 , no. 1 , pp. 328-334 . https://doi.org/10.1039/C7CY01205E | en |
dc.identifier.issn | 2044-4753 | |
dc.identifier.other | Bibtex: urn:9515631e93afa20f5983e30ac40d5c86 | |
dc.identifier.other | ORCID: /0000-0002-2444-1244/work/59464599 | |
dc.identifier.uri | https://hdl.handle.net/10023/16601 | |
dc.description | The authors thanks the EPSRC for funding in the initial stages of this work from EP/J018139/1 and from the DTG. | en |
dc.description.abstract | The challenging reaction of unactivated ortho-substituted aromatic ethers with Grignard reagents has been found to be most effectively catalysed using nickel complexes of less sterically hindered ligands. Air stable, cheap, commercially available [NiCl2(PnBu3)2] stands out as an improved catalyst for this type of transformation. The improved results with this catalyst even extend to some couplings of a more activated substrate when examined at higher temperatures and at catalyst loadings down to 0.1 mol%. Unusual induction periods in these latter reactions have been related to the by-product magnesium salts acting as co-catalysts. | |
dc.format.extent | 1241310 | |
dc.language.iso | eng | |
dc.relation.ispartof | Catalysis Science & Technology | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1039/C7CY01205E | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-12-01 | |
dc.identifier.grantnumber | EP/J018139/1 | en |
dc.identifier.grantnumber | EP/J018139/1 | en |
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