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dc.contributor.authorHarkness, Gavin J.
dc.contributor.authorClarke, Matthew L.
dc.identifier.citationHarkness , G J & Clarke , M L 2018 , ' Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers ' , Catalysis Science & Technology , vol. 8 , no. 1 , pp. 328-334 .
dc.identifier.otherPURE: 251694374
dc.identifier.otherPURE UUID: 82e3c7f4-e10c-4e8f-a739-df1e74fb3612
dc.identifier.otherBibtex: urn:9515631e93afa20f5983e30ac40d5c86
dc.identifier.otherScopus: 85040160788
dc.identifier.otherORCID: /0000-0002-2444-1244/work/59464599
dc.identifier.otherWOS: 000419051200026
dc.descriptionThe authors thanks the EPSRC for funding in the initial stages of this work from EP/J018139/1 and from the DTG.en
dc.description.abstractThe challenging reaction of unactivated ortho-substituted aromatic ethers with Grignard reagents has been found to be most effectively catalysed using nickel complexes of less sterically hindered ligands. Air stable, cheap, commercially available [NiCl2(PnBu3)2] stands out as an improved catalyst for this type of transformation. The improved results with this catalyst even extend to some couplings of a more activated substrate when examined at higher temperatures and at catalyst loadings down to 0.1 mol%. Unusual induction periods in these latter reactions have been related to the by-product magnesium salts acting as co-catalysts.
dc.relation.ispartofCatalysis Science & Technologyen
dc.rights© 2017 the Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at: 10.1039/C7CY01205Een
dc.subjectQD Chemistryen
dc.titleLess hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethersen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.description.statusPeer revieweden

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