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dc.contributor.authorKoutsikou, Stella
dc.contributor.authorMerrison-Hort, Robert
dc.contributor.authorBuhl, Edgar
dc.contributor.authorFerrario, Andrea
dc.contributor.authorLi, Wen-Chang
dc.contributor.authorBorisyuk, Roman
dc.contributor.authorSoffe, Stephen R.
dc.contributor.authorRoberts, Alan
dc.date.accessioned2018-11-12T15:30:15Z
dc.date.available2018-11-12T15:30:15Z
dc.date.issued2018-12-15
dc.identifier.citationKoutsikou , S , Merrison-Hort , R , Buhl , E , Ferrario , A , Li , W-C , Borisyuk , R , Soffe , S R & Roberts , A 2018 , ' A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times ' , The Journal of Physiology , vol. 596 , no. 24 , pp. 6219-6233 . https://doi.org/10.1113/JP276356en
dc.identifier.issn0022-3751
dc.identifier.otherPURE: 255193194
dc.identifier.otherPURE UUID: ba3e277a-85f3-4c3f-8218-0e2bda58a5d3
dc.identifier.otherRIS: urn:0634E4DF76F9B573C433AA1CD7DFFD39
dc.identifier.otherScopus: 85053512953
dc.identifier.otherWOS: 000453214700015
dc.identifier.otherORCID: /0000-0002-1179-6636/work/64361139
dc.identifier.urihttps://hdl.handle.net/10023/16438
dc.descriptionFunding: The Biotechnology and the Biological Sciences Research Council grants: BB/L002353/1, BB/L00111X/1 and BB/L000814/1.en
dc.description.abstractMany motor responses to sensory input, like locomotion or eye movements, are much slower than reflexes. Can simpler animals provide fundamental answers about the cellular mechanisms for motor decisions? Can we observe the ‘accumulation’ of excitation to threshold proposed to underlie decision making elsewhere? We explore how somatosensory touch stimulation leads to the decision to swim in hatchling Xenopus tadpoles. Delays measured to swimming in behaving and immobilised tadpoles are long and variable. Activity in their extensively studied sensory and sensory pathway neurons is too short‐lived to explain these response delays. Instead, whole‐cell recordings from the hindbrain reticulospinal neurons that drive swimming show that these receive prolonged, variable synaptic excitation lasting for nearly a second following a brief stimulus. They fire and initiate swimming when this excitation reaches threshold. Analysis of the summation of excitation requires us to propose extended firing in currently undefined presynaptic hindbrain neurons. Simple models show that a small excitatory recurrent‐network inserted in the sensory pathway can mimic this process. We suggest that such a network may generate slow, variable summation of excitation to threshold. This excitation provides a simple memory of the sensory stimulus. It allows temporal and spatial integration of sensory inputs and explains the long, variable delays to swimming. The process resembles the ‘accumulation’ of excitation proposed for cortical circuits in mammals. We conclude that fundamental elements of sensory memory and decision making are present in the brainstem at a surprisingly early stage in development.
dc.language.isoeng
dc.relation.ispartofThe Journal of Physiologyen
dc.rights© 2018 The Authors The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectDecision-makingen
dc.subjectXenopus laevisen
dc.subjectReticulospinal neuronsen
dc.subjectLocomotionen
dc.subjectSomatosensoryen
dc.subjectBF Psychologyen
dc.subjectNDASen
dc.subjectBDCen
dc.subject.lccBFen
dc.titleA simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response timesen
dc.typeJournal articleen
dc.contributor.sponsorBBSRCen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1113/JP276356
dc.description.statusPeer revieweden
dc.identifier.grantnumberBB/L00111X/1en


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