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dc.contributor.authorKosikova, Tamara
dc.contributor.authorPhilp, Douglas
dc.identifier.citationKosikova , T & Philp , D 2017 , ' Exploring the emergence of complexity using synthetic replicators ' , Chemical Society Reviews , vol. 46 , no. 23 , pp. 7274-7305 .
dc.identifier.otherPURE: 251504421
dc.identifier.otherPURE UUID: 9cd45b4f-b9d5-4e0c-943b-ece4d3ad7c93
dc.identifier.otherScopus: 85035309865
dc.identifier.otherORCID: /0000-0002-9198-4302/work/56639235
dc.identifier.otherWOS: 000417020300009
dc.descriptionThis work was supported by University of St Andrews and the award of a Postgraduate Studentship from Engineering and Physical Sciences Research Council (EP/K503162/1) to T. K.en
dc.description.abstractA significant number of synthetic systems capable of replicating themselves or entities that are complementary to themselves have appeared in the last 30 years. Building on an understanding of the operation of synthetic replicators in isolation, this field has progressed to examples where catalytic relationships between replicators within the same network and the extant reaction conditions play a role in driving phenomena at the level of the whole system. Systems chemistry has played a pivotal role in the attempts to understand the origin of biological complexity by exploiting the power of synthetic chemistry, in conjunction with the molecular recognition toolkit pioneered by the field of supramolecular chemistry, thereby permitting the bottom-up engineering of increasingly complex reaction networks from simple building blocks. This review describes the advances facilitated by the systems chemistry approach in relating the expression of complex and emergent behaviour in networks of replicators with the connectivity and catalytic relationships inherent within them. These systems, examined within well-stirred batch reactors, represent conceptual and practical frameworks that can then be translated to conditions that permit replicating systems to overcome the fundamental limits imposed on selection processes in networks operating under closed conditions. This shift away from traditional spatially homogeneous reactors towards dynamic and non-equilibrium conditions, such as those provided by reaction-diffusion reaction formats, constitutes a key change that mimics environments within cellular systems, which possess obvious compartmentalisation and inhomogeneity.
dc.relation.ispartofChemical Society Reviewsen
dc.rightsCopyright © 2017, The Royal Society of Chemistry This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectQD Chemistryen
dc.titleExploring the emergence of complexity using synthetic replicatorsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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