Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorYau, Adora M. W.
dc.contributor.authorMcLaughlin, John
dc.contributor.authorMaughan, Ronald J.
dc.contributor.authorGilmore, William
dc.contributor.authorAshworth, Jason J.
dc.contributor.authorEvans, Gethin H.
dc.date.accessioned2018-10-10T14:30:13Z
dc.date.available2018-10-10T14:30:13Z
dc.date.issued2018-09-25
dc.identifier.citationYau , A M W , McLaughlin , J , Maughan , R J , Gilmore , W , Ashworth , J J & Evans , G H 2018 , ' A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men ' , Frontiers in Physiology , vol. 9 , 1331 . https://doi.org/10.3389/fphys.2018.01331en
dc.identifier.issn1664-042X
dc.identifier.otherPURE: 256162499
dc.identifier.otherPURE UUID: a6f9d4c7-e781-4c4c-b637-b29e6868c468
dc.identifier.otherRIS: urn:19D09587A9561F0BB3FC9F76D9335A7B
dc.identifier.otherScopus: 85055203227
dc.identifier.otherWOS: 000445632500001
dc.identifier.urihttps://hdl.handle.net/10023/16179
dc.descriptionAY was supported by a Manchester Metropolitan University Ph.D. studentship.en
dc.description.abstractGastric emptying rate in humans is subject to large individual variability, but previous research on the influence of genetics is scarce. Variation in the glucagon-like peptide-1 receptor (GLP1R) gene is a plausible candidate gene to partially explain the high variance. This study aimed to investigate the influence of genetic variation in the GLP1R gene on gastric emptying rate of a glucose solution in humans. Forty eight healthy Caucasian males took part in this investigation. Gastric emptying rate of a 6% glucose solution was assessed using the 13C breath test method and a venous blood sample was obtained from each participant. Participants were genotyped for twenty-seven Tag single nucleotide polymorphisms (SNPs) in the GLP1R locus using Sequenom MassARRAY iPLEX GOLD analysis and MALDI-TOF mass spectrometry. The time at which maximal emptying rate occurred (Tlag) was faster in participants with the CC genotype than in TT and TC genotypes for SNP rs742764: (Median (quartiles) CC, 35 (30-36) min vs. TT, 43 (39-46) min and TC, 41 (39-45) min; P <0.01). Tlag was also slower in participants with the AA genotype compared to the TT and TA genotypes for SNP rs2254336: (AA, 43 (39-49) min vs. TT, 36 (34-41) min and TA, 39 (35-42) min; P <0.05). Analysis by phenotype also showed differences in half-emptying time (T½) and Tlag for SNPs rs9283907, rs2268657 and rs2254336. Several neighbouring Tag SNPs within the GLP1R gene were found to be associated with gastric emptying rate, and should be further investigated.
dc.language.isoeng
dc.relation.ispartofFrontiers in Physiologyen
dc.rightsCopyright © 2018 Yau, McLaughlin, Maughan, Gilmore, Ashworth and Evans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectGLP-1 receptoren
dc.subjectSingle nucleotide polymorphismen
dc.subjectGastric emptying rateen
dc.subjectGLP-1en
dc.subjectGastrointestinal motilityen
dc.subjectRZ Other systems of medicineen
dc.subjectNDASen
dc.subject.lccRZen
dc.titleA pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Menen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.3389/fphys.2018.01331
dc.description.statusPeer revieweden


This item appears in the following Collection(s)

Show simple item record