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Gliotransmission and adenosinergic modulation : insights from mammalian spinal motor networks
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dc.contributor.author | Acton, David | |
dc.contributor.author | Miles, Gareth Brian | |
dc.date.accessioned | 2018-09-26T23:45:53Z | |
dc.date.available | 2018-09-26T23:45:53Z | |
dc.date.issued | 2017-12 | |
dc.identifier | 251117784 | |
dc.identifier | f9aff986-97ed-4aac-9163-efcddd05ef3e | |
dc.identifier | 85043780483 | |
dc.identifier | 000424042900003 | |
dc.identifier.citation | Acton , D & Miles , G B 2017 , ' Gliotransmission and adenosinergic modulation : insights from mammalian spinal motor networks ' , Journal of Neurophysiology , vol. 118 , no. 6 , pp. 3311-3327 . https://doi.org/10.1152/jn.00230.2017 | en |
dc.identifier.issn | 0022-3077 | |
dc.identifier.uri | https://hdl.handle.net/10023/16082 | |
dc.description | D Acton was supported by funds from a Wellcome Trust Institutional Strategic Support Fund grant. GBM received support from Biotechnology and Biological Science Research Grant BB/M021793/1. | en |
dc.description.abstract | Astrocytes are proposed to converse with neurons at tripartite synapses, detecting neurotransmitter release and responding with release of gliotransmitters, which in turn modulate synaptic strength and neuronal excitability. However, a paucity of evidence from behavioral studies calls into question the importance of gliotransmission for the operation of the nervous system in healthy animals. Central pattern generator (CPG) networks in the spinal cord and brainstem coordinate the activation of muscles during stereotyped activities such as locomotion, inspiration and mastication, and may therefore provide tractable models in which to assess the contribution of gliotransmission to behaviorally relevant neural activity. Here, we review evidence for gliotransmission within spinal locomotor networks, including studies indicating that adenosine derived from astrocytes regulates the speed of locomotor activity via metamodulation of dopamine signaling. | |
dc.format.extent | 1608602 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Neurophysiology | en |
dc.subject | Spinal cord | en |
dc.subject | Gliotransmission | en |
dc.subject | Adenosine | en |
dc.subject | Locomotion | en |
dc.subject | CPG | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject.lcc | RC0321 | en |
dc.title | Gliotransmission and adenosinergic modulation : insights from mammalian spinal motor networks | en |
dc.type | Journal item | en |
dc.contributor.sponsor | BBSRC | en |
dc.contributor.sponsor | The Wellcome Trust | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | 10.1152/jn.00230.2017 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-09-27 | |
dc.identifier.grantnumber | BB/M021793/1 | en |
dc.identifier.grantnumber | en |
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