Mechanisms and consequences of positive-strand RNA virus recombination
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Genetic recombination in positive-strand RNA viruses is a significant evolutionary mechanism that drives the creation of viral diversity by the formation of novel chimaeric genomes. The process and its consequences, for example the generation of viruses with novel phenotypes, has historically been studied by analysis of the end products. More recently, with an appreciation that there are both replicative and non-replicative mechanisms at work, and with new approaches and techniques to analyse intermediate products, the viral and cellular factors that influence the process are becoming understood. The major influence on replicative recombination is the fidelity of viral polymerase, although RNA structures and sequences may also have an impact. In replicative recombination the viral polymerase is necessary and sufficient, although roles for other viral or cellular proteins may exist. In contrast, non-replicative recombination appears to be mediated solely by cellular components. Despite these insights, the relative importance of replicative and non-replicative mechanisms is not clear. Using single-stranded positive-sense RNA viruses as exemplars, we review the current state of understanding of the processes and consequences of recombination.
Bentley , K & Evans , D J 2018 , ' Mechanisms and consequences of positive-strand RNA virus recombination ' , Journal of General Virology , vol. 99 , no. 10 , pp. 1345-1356 . https://doi.org/10.1099/jgv.0.001142
Journal of General Virology
© 2018, the Author(s). This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1099/jgv.0.001142
DescriptionK. B. is supported by Biotechnology and Biological Sciences Research Council award BB/M009343/1 to D. J. E.
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