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dc.contributor.authorTolomeo, Serenella
dc.contributor.authorMatthews, Keith
dc.contributor.authorSteele, Douglas
dc.contributor.authorBaldacchino, Alex
dc.date.accessioned2018-09-13T23:35:41Z
dc.date.available2018-09-13T23:35:41Z
dc.date.issued2018-02-02
dc.identifier.citationTolomeo , S , Matthews , K , Steele , D & Baldacchino , A 2018 , ' Compulsivity in opioid dependence ' Progress in Neuro-Psychopharmacology & Biological Psychiatry , vol. 81 , pp. 333-339 . https://doi.org/10.1016/j.pnpbp.2017.09.007en
dc.identifier.issn0278-5846
dc.identifier.otherPURE: 251052067
dc.identifier.otherPURE UUID: dd863243-26cf-46f2-8e8a-e48e3b2ff52c
dc.identifier.otherScopus: 85029747826
dc.identifier.otherORCID: /0000-0002-5388-7376/work/60196781
dc.identifier.otherWOS: 000414901100036
dc.identifier.urihttp://hdl.handle.net/10023/16027
dc.descriptionThis study was part funded by an unrestricted educational grant provided by Schering-Plough and a grant by an Anonymous Trust. Study support was also provided by the Scottish Mental Health Research Network. AB has received educational grants from Schering Plough and he has received research project funding from Schering-Plough, Merck Serono, and Indivior.en
dc.description.abstractObjective: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence. Method: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n=24), ii) heroin users stabilised on methadone maintenance treatment (n=48), iii) abstinent participants with ahistory of opioid dependence due to heroin use (n=24) and iv) healthy controls(n=50). Compulsivity was measured using Intra/Extra-Dimensional (IED) Task and impulsivity was measured using the Cambridge Gambling Task (CGT).Structural Magnetic Resonance Imaging (MRI) data were also obtained. Results: As hypothesised, compulsivity was negatively associated with impulsivity (p<0.02). Testing for the neural substrates of compulsivity versus impulsivity, we found a higher compulsivity/impulsivity ratio associated with significantly decreased white matter adjacent to the nucleus accumbens, bed nucleus of stria terminalis and rostral cingulate in the abstinent group,compared to the other opioid dependent groups. In addition, self-reported duration of opioid exposure correlated negatively with bilateral globus pallidus grey matter reductions. Conclusion: Our findings are consistent with Volkow & Koob’s addiction models and underline the important role of compulsivity versus impulsivity inopioid dependence. Our results have implications for the treatment of opioid dependence supporting the assertion of different behavioural and biological phenotypes in the opioid dependence and abstinence syndromes.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen
dc.rights© 2017 Elsevier Ltd. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.pnpbp.2017.09.007en
dc.subjectDependenceen
dc.subjectMethadoneen
dc.subjectHeroinen
dc.subjectImagingen
dc.subjectCognitionen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectNDASen
dc.subject.lccRC0321en
dc.subject.lccRMen
dc.titleCompulsivity in opioid dependenceen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews.Centre for Minorities Research (CMR)en
dc.identifier.doihttps://doi.org/10.1016/j.pnpbp.2017.09.007
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-09-14
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0278584617303913#appd001en


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