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dc.contributor.authorSmeets, E.
dc.contributor.authorLynch, A. G.
dc.contributor.authorPrekovic, S.
dc.contributor.authorVan den Broeck, T.
dc.contributor.authorMoris, L
dc.contributor.authorHelsen, C.
dc.contributor.authorJoniau, S.
dc.contributor.authorClaessens, F.
dc.contributor.authorMassie, C. E.
dc.identifier.citationSmeets , E , Lynch , A G , Prekovic , S , Van den Broeck , T , Moris , L , Helsen , C , Joniau , S , Claessens , F & Massie , C E 2018 , ' The role of TET-mediated DNA hydroxymethylation in prostate cancer ' , Molecular and Cellular Endocrinology , vol. 462 , no. A , pp. 41-55 .
dc.identifier.otherORCID: /0000-0002-7876-7338/work/36661764
dc.descriptionMassie C. is funded by an ERC grant (337905) and acknowledges support of the University of Cambridge, the Cancer Research UK Cambridge Centre and Hutchison Whampoa Limited. Claessens F. and Joniau S. hold grants from Fonds Wetenschappelijk Onderzoek-Vlaanderen (GOA9816N, G.0684.12N, G.0830.13N). Van den Broeck T. is supported by a PhD fellowship from Fonds Wetenschappelijk Onderzoek-Vlaanderen (11ZO616N). This work was also supported by the KU Leuven (GOA/15/017) and Kom op tegen Kanker.en
dc.description.abstractTen-eleven translocation (TET) proteins are recently characterized dioxygenases that regulate demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine and further derivatives. The recent finding that 5hmC is also a stable and independent epigenetic modification indicates that these proteins play an important role in diverse physiological and pathological processes such as neural and tumor development. Both the genomic distribution of (hydroxy)methylation and the expression and activity of TET proteins are dysregulated in a wide range of cancers including prostate cancer. Up to now it is still unknown how changes in TET and 5(h)mC profiles are related to the pathogenesis of prostate cancer. In this review, we explore recent advances in the current understanding of how TET expression and function are regulated in development and cancer. Furthermore, we look at the impact on 5hmC in prostate cancer and the potential underlying mechanisms. Finally, we tried to summarize the latest techniques for detecting and quantifying global and locus-specific 5hmC levels of genomic DNA.
dc.relation.ispartofMolecular and Cellular Endocrinologyen
dc.subjectProstate canceren
dc.subjectDNA hydroxymethylationen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQH426 Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleThe role of TET-mediated DNA hydroxymethylation in prostate canceren
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.description.statusPeer revieweden

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