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dc.contributor.authorSmeets, E.
dc.contributor.authorLynch, A. G.
dc.contributor.authorPrekovic, S.
dc.contributor.authorVan den Broeck, T.
dc.contributor.authorMoris, L
dc.contributor.authorHelsen, C.
dc.contributor.authorJoniau, S.
dc.contributor.authorClaessens, F.
dc.contributor.authorMassie, C. E.
dc.date.accessioned2018-08-31T23:35:50Z
dc.date.available2018-08-31T23:35:50Z
dc.date.issued2018-02-15
dc.identifier.citationSmeets , E , Lynch , A G , Prekovic , S , Van den Broeck , T , Moris , L , Helsen , C , Joniau , S , Claessens , F & Massie , C E 2018 , ' The role of TET-mediated DNA hydroxymethylation in prostate cancer ' , Molecular and Cellular Endocrinology , vol. 462 , no. A , pp. 41-55 . https://doi.org/10.1016/j.mce.2017.08.021en
dc.identifier.issn0303-7207
dc.identifier.otherPURE: 251028147
dc.identifier.otherPURE UUID: 805506a7-8051-465e-b683-e1a69c3892e4
dc.identifier.otherPubMed: 28870782
dc.identifier.otherScopus: 85029469198
dc.identifier.otherORCID: /0000-0002-7876-7338/work/36661764
dc.identifier.urihttps://hdl.handle.net/10023/15937
dc.descriptionMassie C. is funded by an ERC grant (337905) and acknowledges support of the University of Cambridge, the Cancer Research UK Cambridge Centre and Hutchison Whampoa Limited. Claessens F. and Joniau S. hold grants from Fonds Wetenschappelijk Onderzoek-Vlaanderen (GOA9816N, G.0684.12N, G.0830.13N). Van den Broeck T. is supported by a PhD fellowship from Fonds Wetenschappelijk Onderzoek-Vlaanderen (11ZO616N). This work was also supported by the KU Leuven (GOA/15/017) and Kom op tegen Kanker.en
dc.description.abstractTen-eleven translocation (TET) proteins are recently characterized dioxygenases that regulate demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine and further derivatives. The recent finding that 5hmC is also a stable and independent epigenetic modification indicates that these proteins play an important role in diverse physiological and pathological processes such as neural and tumor development. Both the genomic distribution of (hydroxy)methylation and the expression and activity of TET proteins are dysregulated in a wide range of cancers including prostate cancer. Up to now it is still unknown how changes in TET and 5(h)mC profiles are related to the pathogenesis of prostate cancer. In this review, we explore recent advances in the current understanding of how TET expression and function are regulated in development and cancer. Furthermore, we look at the impact on 5hmC in prostate cancer and the potential underlying mechanisms. Finally, we tried to summarize the latest techniques for detecting and quantifying global and locus-specific 5hmC levels of genomic DNA.
dc.language.isoeng
dc.relation.ispartofMolecular and Cellular Endocrinologyen
dc.rights© 2017 Elsevier Ltd. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.mce.2017.08.021en
dc.subjectProstate canceren
dc.subjectEpigeneticsen
dc.subjectTETen
dc.subjectDNA hydroxymethylationen
dc.subject5hmCen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQH426 Geneticsen
dc.subjectT-NDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0254en
dc.subject.lccQH426en
dc.titleThe role of TET-mediated DNA hydroxymethylation in prostate canceren
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.1016/j.mce.2017.08.021
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-09-01


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