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dc.contributor.authorParker, Darren
dc.contributor.authorWiberg, R. Axel W.
dc.contributor.authorTrivedi, Urmi
dc.contributor.authorTyukmaeva, Venera I.
dc.contributor.authorGharbi, Karim
dc.contributor.authorButlin, Roger K.
dc.contributor.authorHoikkala, Anneli
dc.contributor.authorKankare, Maaria
dc.contributor.authorRitchie, Michael
dc.identifier.citationParker , D , Wiberg , R A W , Trivedi , U , Tyukmaeva , V I , Gharbi , K , Butlin , R K , Hoikkala , A , Kankare , M & Ritchie , M 2018 , ' Inter and Intraspecific genomic divergence in Drosophila montana shows evidence for cold adaptation ' , Genome Biology and Evolution , vol. 10 , no. 8 , pp. 2086–2101 .
dc.identifier.otherPURE: 254611168
dc.identifier.otherPURE UUID: 47eeae64-17d9-4fe2-8b49-8164aa35f26d
dc.identifier.otherORCID: /0000-0001-7913-8675/work/46761159
dc.identifier.otherWOS: 000444553900020
dc.descriptionThis work was supported by the Academy of Finland to AH (projects 132619 and 267244) and to MK (projects 268214 and 272927) and NERC (UK) funding to MGR (grants NE/E015255/1 and NE/J020818/1) and PhD studentship to DJP (NE/I528634/1).en
dc.description.abstractThe genomes of species that are ecological specialists will likely contain signatures of genomic adaptation to their niche. However, distinguishing genes related to ecological specialism from other sources of selection and more random changes is a challenge. Here we describe the genome of Drosophila montana, which is the most extremely cold-adapted Drosophila species. We use branch tests to identify genes showing accelerated divergence in contrasts between cold- and warm adapted species and identify about 250 genes that show differences, possibly driven by a lower synonymous substitution rate in cold-adapted species. We look for evidence of accelerated divergence between D. montana and D. virilis, a previously sequenced relative, and do not find strong evidence for divergent selection on coding sequence variation. Divergent genes are involved in a variety of functions, including cuticular and olfactory processes. We also re-sequenced three populations of D. montana from its ecological and geographic range. Outlier loci were more likely to be found on the X chromosome and there was a greater than expected overlap between population outliers and those genes implicated in cold adaptation between Drosophila species, implying some continuity of selective process at these different evolutionary scales.
dc.relation.ispartofGenome Biology and Evolutionen
dc.rightsCopyright The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly citeden
dc.subjectCold toleranceen
dc.subjectDrosophilia montanaen
dc.subjectEcological adaptationen
dc.subjectComparative genomicsen
dc.subjectQH301 Biologyen
dc.titleInter and Intraspecific genomic divergence in Drosophila montana shows evidence for cold adaptationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.description.statusPeer revieweden

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