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Bifurcations of limit cycles in a reduced model of the Xenopus tadpole central pattern generator

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Date
18/07/2018
Author
Ferrario, Andrea
Merrison-Hort, Robert
Soffe, Stephen R.
Li, Wen-Chang
Borisyuk, Roman
Keywords
Bifurcation Analysis
Central patter generator
Swimming
Synchrony
Xenopus Tadpole
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Neuroscience (miscellaneous)
NDAS
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Abstract
We present the study of a minimal microcircuit controlling locomotion in two-day-old Xenopus tadpoles. During swimming, neurons in the spinal central pattern generator (CPG) generate anti-phase oscillations between left and right half-centres. Experimental recordings show that the same CPG neurons can also generate transient bouts of long-lasting in-phase oscillations between left-right centres. These synchronous episodes are rarely recorded and have no identified behavioural purpose. However, metamorphosing tadpoles require both anti-phase and in-phase oscillations for swimming locomotion. Previous models have shown the ability to generate biologically realistic patterns of synchrony and swimming oscillations in tadpoles, but a mathematical description of how these oscillations appear is still missing. We define a simplified model that incorporates the key operating principles of tadpole locomotion. The model generates the various outputs seen in experimental recordings, including swimming and synchrony. To study the model, we perform detailed one- and two-parameter bifurcation analysis. This reveals the critical boundaries that separate different dynamical regimes and demonstrates the existence of parameter regions of bi-stable swimming and synchrony. We show that swimming is stable in a significantly larger range of parameters, and can be initiated more robustly, than synchrony. Our results can explain the appearance of long-lasting synchrony bouts seen in experiments at the start of a swimming episode.
Citation
Ferrario , A , Merrison-Hort , R , Soffe , S R , Li , W-C & Borisyuk , R 2018 , ' Bifurcations of limit cycles in a reduced model of the Xenopus tadpole central pattern generator ' , Journal of Mathematical Neuroscience , vol. 8 , no. 1 , 10 . https://doi.org/10.1186/s13408-018-0065-9
Publication
Journal of Mathematical Neuroscience
Status
Peer reviewed
DOI
https://doi.org/10.1186/s13408-018-0065-9
ISSN
2190-8567
Type
Journal article
Rights
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Description
This work was supported by the UK Biotechnology and Biological Sciences Research Council (BBSRC, grant numbers BB/L002353/1; BB/L000814/1; BB/L00111X/1). AF was supported by a PhD studentship from Plymouth University.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/15835

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