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dc.contributor.authorGriffin, Laura Susan
dc.contributor.authorGloster, Tracey Maureen
dc.date.accessioned2018-08-16T09:30:05Z
dc.date.available2018-08-16T09:30:05Z
dc.date.issued2017-08-01
dc.identifier.citationGriffin , L S & Gloster , T M 2017 , ' The enzymatic degradation of heparan sulfate ' , Protein & Peptide Letters , vol. 24 , no. 8 , pp. 710-722 . https://doi.org/10.2174/0929866524666170724113452en
dc.identifier.issn0929-8665
dc.identifier.otherPURE: 255285491
dc.identifier.otherPURE UUID: 00cc2ae9-759e-4d66-a749-05f568ed943c
dc.identifier.otherScopus: 85033574818
dc.identifier.otherWOS: 000413686800005
dc.identifier.urihttp://hdl.handle.net/10023/15828
dc.descriptionFunding: Wellcome Trust (Research Career Development Fellowship to TMG) and the BBSRC (studentship to LSG).en
dc.description.abstractGlycosaminoglycans (GAGs) such as heparan sulfate (HS) interact with a number of factors in the extracellular matrix (ECM) and as a consequence play a key role in the metabolic processes occurring within the cell. The dynamic synthesis and degradation of HS (and all GAGs) are necessary for ensuring that optimal chains are present for these functions. The degradation of HS begins at the cell surface and finishes in the lysosome, after which components can be recycled. Deficiencies or mutations in the lysosomal enzymes that process GAGs result in rare Mucopolysaccharidoses disorders (MPSs). There are few treatments available for these genetically inherited diseases and those that are available often do not treat the neurological symptoms of the disease. In this review, we discuss the enzymes involved in the degradation of HS and their related diseases, with emphasis on those located in the lysosome.
dc.language.isoeng
dc.relation.ispartofProtein & Peptide Lettersen
dc.rights© 2017, Bentham Science Publishers. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.2174/0929866524666170724113452en
dc.subjectGlycosaminoglycanen
dc.subjectHeparan sulfateen
dc.subjectDegradationen
dc.subjectLysosomeen
dc.subjectMucopolysaccharidosesen
dc.subjectEnzymesen
dc.subjectQD Chemistryen
dc.subjectQH301 Biologyen
dc.subject.lccQDen
dc.subject.lccQH301en
dc.titleThe enzymatic degradation of heparan sulfateen
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.2174/0929866524666170724113452
dc.description.statusPeer revieweden


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